The Effect of Bariatric Surgery on Anthropometric Indices, Gut Microbiome, and Microbial Metabolites in Patients With Nafld: A Systematic Review Publisher



A Hajizadeh AYLIN ; H Ejtahed Haniehsadat S ; Mr Fadaeifard Mohammad REZA ; F Ziamanesh FATEME ; S Hasaniranjbar SHIRIN ; M Hemmatabadi MAHBUBEH ; N Shirzad NOOSHIN
Source: Egyptian Liver Journal Published:2025

Abstract

Obesity is a global health challenge linked with NAFLD (nonalcoholic fatty liver disease). Bariatric surgery can induce NAFLD remission by altering gut microbiota. This study evaluates bariatric surgery’s effects on anthropometric indices, gut microbiota, and microbial metabolites in NAFLD patients. Data from major databases up to October 2023 were analyzed. Studies were assessed for quality using the Newcastle–Ottawa scale (NOS). Eleven studies were reviewed. Bariatric surgery increased Bacteroides, Akkermansia, and “Proteobacteria” and decreased “Actinomycetota.” It also altered bile acid profiles, reducing primary conjugated bile acids and increasing secondary conjugated bile acids, particularly glycoursodeoxycholic acid (GUDCA). Improvements in body mass index were observed in NAFLD patient’s post-surgery. Bariatric surgery impacts gut microbiota and bile acid profiles, playing a potential role in NAFLD remission. Further extensive studies are required due to study inconsistencies. © 2025 Elsevier B.V., All rights reserved.