Combination Therapy of Phosphatidylserine Liposome With Cyclosporine a Improves Nephrotoxicity and Attenuates Delayed-Type Hypersensitivity Response Publisher Pubmed



Komeili M¹ ; Noorbakhsh F² ; Esmaili J³ ; Muhammadnejad A⁴ ; Hassanzadeh G⁵ ; Dehpour AR^{3, 6} ; Goudarzi R⁷ ; Partoazar A^{3, 6} Show Affiliations
Source: Life Sciences Published:2021

Abstract

This study aimed to evaluate the antioxidant capacity of phosphatidylserine liposome (PS) against oxidative stress due to cyclosporine A (CsA) and concurrent administration of PS and CsA on the attenuation of immune response. The effect of oral PS was evaluated on biochemical and oxidative renal markers and histopathology of nephrotic rats receiving CsA. The effect of co-administration of PS with CsA was also assessed on DTH (delayed-type hypersensitivity) reaction of immunized rats. The cytokines production level of IL-2 (Interleukin-2) and IFN-γ (Interferon gamma) was measured in immunized rat's splenocytes. PS treatment significantly (P < 0.05) reduced Cr and BUN of serum and MDA (malondialdehyde) in kidney tissue, and increased SOD (superoxide dismutase) and CAT (Catalase) of kidney tissue in CsA-nephrotic rats. Histopathology data indicated significantly (P < 0.05) nephrotoxicity improvement after 25-day treatment with PS. Furthermore, CsA plus PS administration significantly reduced DTH response and cytokines production of IL-2 and IFN-γ in immunized rats. In conclusion, coadministration of CsA plus PS may overcome oxidative stress and improve the performance of organ transplantation or autoimmune therapy. © 2020 Elsevier Inc.