Could the Administration of Sglt2i Agents Serve As a Viable Prophylactic Approach Against Cni-Induced Toxicities?

Could the Administration of Sglt2i Agents Serve As a Viable Prophylactic Approach Against Cni-Induced Toxicities? Publisher

Molaei E¹ ; Molaei A² ; Dashtikhavidaki S^{1, 3} ; Nasiritoosi M³ ; Abbasi MR⁴ ; Jafarian A³

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1. Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2. University of Medical Sciences, Mashhad, Iran
3. Liver Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran
4. Nephrology Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Medical Hypotheses Published:2024

Abstract

Calcineurin inhibitors (CNIs) are a class of immunosuppressants utilized to manage autoimmune disorders and to prevent rejection in solid organ transplantations. CNIs are associated with various side effects, including new-onset diabetes, dyslipidemia, hypertension, nephrotoxicity, cardiovascular risks, electrolyte imbalances, and neurotoxicity. Preventing these complications is crucial for improving the patients’ quality of life and survival. One strategy widely used to prevent these side effects is to employ a multi-drug immunosuppressive regimen to eliminate or reduce the CNI dose. However, the efficacy of this strategy is relatively low and there is a possibility of causing side effects by other drugs. As a result, novel approaches are needed to prevent or manage complications related to CNIs. Sodium-glucose cotransporter 2 inhibitors (SGLT2is) are a type of antidiabetic medication that has gained increased usage. Preliminary clinical trials suggest that administering these drugs to diabetic patients is linked to improved renal and cardiovascular outcomes. Their prescription has also been recommended for non-diabetic patients with chronic kidney disease (CKD) and heart failure (HF). Our hypothesis is that SGLT2is can prevent or delay metabolic and vascular complications associated with CNIs due to their anti-diabetic, anti-hypertensive, anti-inflammatory, anti-fibrotic, antioxidant, and anti-apoptotic effects, as well as their ability to improve endothelial function. Additionally, SGLT2is have the potential to reverse electrolyte imbalances and neurological disorders caused by CNIs based on their effects on tubular function and neuroprotective properties. If the hypothesis were to be confirmed, the implications for science would be the prolongation of lifespan in patients treated with CNIs by targeting several side effects mechanisms with one drug. © 2024 Elsevier Ltd

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Style	Citing Format
MLA	Molaei E, et al.. "Could the Administration of Sglt2i Agents Serve As a Viable Prophylactic Approach Against Cni-Induced Toxicities?." Medical Hypotheses, vol. 189, no. , 2024, pp. -.
APA	Molaei E, Molaei A, Dashtikhavidaki S, Nasiritoosi M, Abbasi MR, Jafarian A (2024). Could the Administration of Sglt2i Agents Serve As a Viable Prophylactic Approach Against Cni-Induced Toxicities?. Medical Hypotheses, 189(), -.
Chicago	Molaei E, Molaei A, Dashtikhavidaki S, Nasiritoosi M, Abbasi MR, Jafarian A. "Could the Administration of Sglt2i Agents Serve As a Viable Prophylactic Approach Against Cni-Induced Toxicities?." Medical Hypotheses 189, no. (2024): -.
Harvard	Molaei E et al. (2024) 'Could the Administration of Sglt2i Agents Serve As a Viable Prophylactic Approach Against Cni-Induced Toxicities?', Medical Hypotheses, 189(), pp. -.
Vancouver	Molaei E, Molaei A, Dashtikhavidaki S, Nasiritoosi M, Abbasi MR, Jafarian A. Could the Administration of Sglt2i Agents Serve As a Viable Prophylactic Approach Against Cni-Induced Toxicities?. Medical Hypotheses. 2024;189():-.
BibTex	@article{ author = {Molaei E and Molaei A and Dashtikhavidaki S and Nasiritoosi M and Abbasi MR and Jafarian A}, title = {Could the Administration of Sglt2i Agents Serve As a Viable Prophylactic Approach Against Cni-Induced Toxicities?}, journal = {Medical Hypotheses}, volume = {189}, number = {}, pages = {-}, year = {2024} }
RIS	TY - JOUR AU - Molaei E AU - Molaei A AU - Dashtikhavidaki S AU - Nasiritoosi M AU - Abbasi MR AU - Jafarian A TI - Could the Administration of Sglt2i Agents Serve As a Viable Prophylactic Approach Against Cni-Induced Toxicities? JO - Medical Hypotheses VL - 189 IS - SP - EP - PY - 2024 ER -

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