Is There an Association Between a Plant-Based Eating Pattern and Clinical Findings of a Migraine Headache? Publisher



Karimi E^{1, 2} ; Tirani SA³ ; Azimi ES⁴ ; Askari G³ ; Ashabi A⁵ ; Arab A³ Show Affiliations
Source: Frontiers in Nutrition Published:2023

Abstract

Aims: The present study was conducted among Iranian individuals diagnosed with migraine headaches to investigate the association between plant-based eating patterns and the clinical features of a migraine headache. Methods: In total, 262 patients aged 20–50 years who were diagnosed with migraine headaches were included in the current cross-sectional study. Participants’ dietary intake was assessed using a validated 168-item, semi-quantitative food frequency questionnaire (FFQ). Three versions of the plant-based diet index (PDI) comprising overall PDI, healthy PDI (hPDI), and unhealthy PDI (uPDI) were generated. Headache frequency, duration, and severity were assessed via a 30-day headache diary. Migraine-related disability was assessed with a validated version of the headache impact test (HIT-6) questionnaire. Serum nitric oxide (NO) was measured using the Griess method utilizing serum samples. Results: After controlling for potential confounders, an increase in mean PDI score from 48.22 to 61.67 decreased the frequency of headaches by −2.95 (95% CI: 0.06, 0.53; ptrend = 0.005). PDI was inversely associated with serum levels of NO in those with the highest scores of PDI compared to those with the lowest scores after adjustment for confounders (β = −7.69; 95% CI: −14.68, −0.69; ptrend = 0.028). After adjustment for potential confounders, an increase in the mean hPDI score from 47.96 to 65.25 decreased serum levels of NO by −11.92 (95% CI: −19.74, −4.10; ptrend = 0.003). Conclusion: Our findings suggest that higher adherence to a plant-based eating style, as evidenced by higher PDI and hPDI values, was significantly associated with lower headache frequency and serum levels of NO. Copyright © 2023 Karimi, Tirani, Azimi, Askari, As’habi and Arab.