Cardiovascular System Is at Higher Risk of Affecting by Covid-19 Publisher Pubmed



Nejadghaderi SA^{1, 2} ; Heidari A^{1, 3} ; Shakerian N^{1, 4} ; Saghazadeh A^{1, 5} ; Rezaei N^{5, 6, 7} Show Affiliations
Source: Acta Biomedica Published:2020

Abstract

Summary. SARS-CoV-2 has shown its potential to cause severe manifestations among individuals with un-derlying cardiovascular disease (CVD). The patients infected with SARS-CoV-2 with pre-existing CVD are more likely to relapse. There are several reasons, including the prolonged hospitalization time as a conse-quence of their more severe illness and aberrant expression of angiotensin-converting enzyme 2 (ACE2) – the cell surface receptor of SARS-COV2 that is present on cardiac cells – and using drugs such as ACE inhibitors and angiotensin receptor blockers (ARBs) that alter the expression of ACE2. Besides, SARS-CoV-2 shares structural similarities with SARS-CoV-1, and that patients recovered from SARS-CoV1 have shown an increased risk of developing inflammatory, metabolic, and cardiac diseases. It makes some concerns that people who recovered from SARS-CoV2 are also liable to develop these chronic conditions later. Further studies should investigate the probability of recurrence of COVID-19 in patients with CVD and the development of approaches for the prevention of chronic inflammatory conditions in patients with CVD who recovered from COVID-19. (www.actabiomedica.it). © Mattioli 1885.