Tehran University of Medical Sciences

Science Communicator Platform

Share By
Plant-Mediated Green Nanoparticles: Combining Nanometal and Biometabolite Potential for Alzheimer’S Treatment Publisher Pubmed



Behzad F ; Leili F R ; Ebrahimi M ; Moafi M ; Kenari P B ; Alizadeh A ; Adeli S ; Khosravani M ; Jadidi Kouhbanani M A ; Fahanik Babaei J
Authors

Source: BioMedical Engineering Online Published:2026


Abstract

Alzheimer’s disease (AD) can cause cognitive and memory dysfunction due to insufficient acetylcholine (ACh). In principle, acetylcholinesterase (AChE) hydrolyzes ACh into acetic acid and choline, rendering the latter inactive. Acetylcholinesterase inhibitors (AChEI) are currently the main treatment strategy used to increase ACh availability and decrease the effects of cholinergic loss. The FDA has currently approved donepezil, rivastigmine, and galantamine (GAL) as AchEI drugs to treat AD. Among these drugs, only the alkaloid galantamine is found naturally among the AChEIs. The synergistic effect of plant metabolites and metal nanoparticles (MNPs) presents a promising avenue for AD treatment. Green synthesis approach leverages the unique properties of MNPs combined with the therapeutic potential of plant-derived compounds. In the present review, recent developments in nanotechnology, including the green synthesis of MNPs, have been discussed in relation to the treatment of AD. Given the recent advancements, we hope that the combination of nanotechnology and medicinal plants will eventually result in the development of highly successful strategies for the treatment of AD. © The Author(s) 2026.
Related Docs
View other Related Docs
1. Role of Natural Products for the Treatment of Alzheimer's Disease, European Journal of Pharmacology (2021)
2. Design and Synthesis of New 1,2,3-Triazole-Methoxyphenyl-1,3,4-Oxadiazole Derivatives: Selective Butyrylcholinesterase Inhibitors Against Alzheimer’S Disease, BMC Chemistry (2025)
3. Prospects of Saffron and Its Derivatives in Alzheimer's Disease, Archives of Iranian Medicine (2021)
Experts (# of related papers)
View all Related Experts
Mohammad Abdollahi (2)
Elahe Motevaseli (1)
Other Related Docs
4. Recent Advances in the Design and Applications of Amyloid-Β Peptide Aggregation Inhibitors for Alzheimer’S Disease Therapy, Biophysical Reviews (2019)
5. Micrornas Modulation by Curcumin, Catalpol, and Other Natural Products in Alzheimer’S Disease: A Review, Molecular Biology Reports (2025)
6. Cinnamon, a Promising Prospect Towards Alzheimer's Disease, Pharmacological Research (2018)
7. Gold Nanoarchitectonics: Promising Nano-Therapeutic Platforms for Multiple Sclerosis Treatment, Heliyon (2026)
8. Advances in Biogenically Synthesized Shaped Metal- and Carbon-Based Nanoarchitectures and Their Medicinal Applications, Advances in Colloid and Interface Science (2020)
9. Pistacia Genus As a Potential Source of Neuroprotective Natural Products, Planta Medica (2019)
10. Exploring the Potential of Metal and Metal Oxide Nanomaterials for Sustainable Water and Wastewater Treatment: A Review of Their Antimicrobial Properties, Chemosphere (2023)
11. Impact of Gold Nanoparticles on Amyloid Β-Induced Alzheimer's Disease in a Rat Animal Model: Involvement of Stim Proteins, ACS Chemical Neuroscience (2019)
12. Green Synthesis and Characterization of Biocompatible Silver Nanoparticles Using Stachys Lavandulifolia Vahl. Extract and Their Antimicrobial Performance Study, Journal of Environmental Treatment Techniques (2020)
13. The Role of Inflammatory Mediators in the Pathogenesis of Alzheimer’S Disease, Sultan Qaboos University Medical Journal (2015)
14. Nanomedicine in the Treatment of Alzheimer’S Disease: Bypassing the Blood-Brain Barrier With Cutting-Edge Nanotechnology, Neurological Sciences (2025)
15. Crossing the Blood-Brain Barrier: Advancing Immunotherapy for Pediatric Brain Tumors, Interdisciplinary Cancer Research (2025)
16. Nanoparticles in Combating Neuronal Dysregulated Signaling Pathways: Recent Approaches to the Nanoformulations of Phytochemicals and Synthetic Drugs Against Neurodegenerative Diseases, International Journal of Nanomedicine (2022)
17. New Racemic Annulated Pyrazolo[1,2-B]Phthalazines As Tacrine-Like Ache Inhibitors With Potential Use in Alzheimer's Disease, European Journal of Medicinal Chemistry (2017)
18. Differential Expression of Neurodegeneration-Related Genes in Sh-Sy5y Neuroblastoma Cells Under the Influence of Cyclophilin A: Could the Enzyme Be a Likely Trigger and Therapeutic Target for Alzheimer’S Disease?, Neurochemical Research (2025)
19. Mesenchymal Stem Cells (Mscs) and Msc-Derived Exosomes in Animal Models of Central Nervous System Diseases: Targeting the Nlrp3 Inflammasome, IUBMB Life (2023)
20. Quercetin Attenuates Depressive-Like Behavior in a Rat Model of Alzheimer’S Disease: Involvement of Galectin-3 Signaling Pathway, Research Journal of Pharmacognosy (2024)