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Microneedling Side Effects and Complications: A Cross-Sectional Study Publisher



Ehsani A ; Razavi Z ; Mohammadi D ; Ehsani A ; Balighi K ; Nourmohammadpour P ; Mohammadabadi MK ; Soltanian Y ; Rahimnia A
Authors

Source: Iranian Journal of Dermatology Published:2025


Abstract

Background: Microneedling is widely used in dermatology due to its effectiveness and favorable safety profile. It promotes dermal collagen and elastin remodeling, thereby improving skin texture, scars, photodamage, and pigmentation disorders. Despite its popularity, microneedling can cause side effects and complications. This study aims to assess the adverse effects of microneedling and to investigate their relationship with demographic and clinical factors. Methods: This cross-sectional study included patients treated with microneedling at Razi Hospital for facial skin conditions. Demographic data, including age, sex, and indication for treatment, were collected prior to treatment. One-month post-procedure, patients were surveyed regarding side effects such as post-inflammatory hyperpigmentation, hypopigmentation, persistent erythema, and itching. The relationship between adverse effects and demographic factors was analyzed. Results: A total of 120 patients participated, with a mean age of 32.41 ± 7.44 years. The majority were women (86.7%), and treatment indications included scars (76.6%), melasma (10.8%), and skin rejuvenation (12.5%). Reported side effects included hyperpigmentation in 6.7%, hypopigmentation in 1.7%, persistent erythema in 2.5%, and itching in 9.2% of patients. Patients with persistent erythema were significantly younger than those without this complication (P = 0.001). No significant relationship was found between adverse effects and either sex or treatment indication. Concl usi on: I t chi ng was t he most f r equent l y r epor t ed si de effect, followed by hyperpigmentation, persistent erythema, and hypopigmentation. Clinicians should address these adverse effects, particularly in younger patients, to ensure optimal care following microneedling. © 2025 Elsevier B.V., All rights reserved.