Synthesis and Anticholinesterase Activity of New Substituted Benzo[D]Oxazole-Based Derivatives

Synthesis and Anticholinesterase Activity of New Substituted Benzo[D]Oxazole-Based Derivatives Publisher Pubmed

Pouramiri B¹ ; Moghimi S² ; Mahdavi M² ; Nadri H³ ; Moradi A³ ; Tavakolinejadkermani E¹ ; Firoozpour L² ; Asadipour A⁴ ; Foroumadi A^{4, 5}

Show Affiliations

1. Department of Chemistry, Faculty of Science, Shahid Bahonar University of Kerman, Kerman, Iran
2. Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Medicinal Chemistry, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4. Department of Medicinal Chemistry, Faculty of Pharmacy and Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
5. Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Chemical Biology and Drug Design Published:2017

Abstract

A series of novel benzo[d]oxazole derivatives (6a–n) have been synthesized and biologically evaluated as potential inhibitors of acetylcholinesterases (AChE) and butyrylcholinesterase (BChE). The chemical structures of all final compounds were confirmed by spectroscopic methods. In vitro studies showed that most of the synthesized compounds are potent acetylcholinesterase and butyrylcholinesterase inhibitors. Among them, compounds 6a and 6j strongly inhibited AChE and BChE activities with IC50 values of 1.03–1.35 and 6.6–8.1 μm, respectively. Docking studies also provided the binding modes of action and identified hydrophobic pi forces as the main interaction. © 2016 John Wiley & Sons A/S

Style	Citing Format
MLA	Pouramiri B, et al.. "Synthesis and Anticholinesterase Activity of New Substituted Benzo[D]Oxazole-Based Derivatives." Chemical Biology and Drug Design, vol. 89, no. 5, 2017, pp. 783-789.
APA	Pouramiri B, Moghimi S, Mahdavi M, Nadri H, Moradi A, Tavakolinejadkermani E, Firoozpour L, Asadipour A, Foroumadi A (2017). Synthesis and Anticholinesterase Activity of New Substituted Benzo[D]Oxazole-Based Derivatives. Chemical Biology and Drug Design, 89(5), 783-789.
Chicago	Pouramiri B, Moghimi S, Mahdavi M, Nadri H, Moradi A, Tavakolinejadkermani E, Firoozpour L, Asadipour A, Foroumadi A. "Synthesis and Anticholinesterase Activity of New Substituted Benzo[D]Oxazole-Based Derivatives." Chemical Biology and Drug Design 89, no. 5 (2017): 783-789.
Harvard	Pouramiri B et al. (2017) 'Synthesis and Anticholinesterase Activity of New Substituted Benzo[D]Oxazole-Based Derivatives', Chemical Biology and Drug Design, 89(5), pp. 783-789.
Vancouver	Pouramiri B, Moghimi S, Mahdavi M, Nadri H, Moradi A, Tavakolinejadkermani E, et al.. Synthesis and Anticholinesterase Activity of New Substituted Benzo[D]Oxazole-Based Derivatives. Chemical Biology and Drug Design. 2017;89(5):783-789.
BibTex	@article{ author = {Pouramiri B and Moghimi S and Mahdavi M and Nadri H and Moradi A and Tavakolinejadkermani E and Firoozpour L and Asadipour A and Foroumadi A}, title = {Synthesis and Anticholinesterase Activity of New Substituted Benzo[D]Oxazole-Based Derivatives}, journal = {Chemical Biology and Drug Design}, volume = {89}, number = {5}, pages = {783-789}, year = {2017} }
RIS	TY - JOUR AU - Pouramiri B AU - Moghimi S AU - Mahdavi M AU - Nadri H AU - Moradi A AU - Tavakolinejadkermani E AU - Firoozpour L AU - Asadipour A AU - Foroumadi A TI - Synthesis and Anticholinesterase Activity of New Substituted Benzo[D]Oxazole-Based Derivatives JO - Chemical Biology and Drug Design VL - 89 IS - 5 SP - 783 EP - 789 PY - 2017 ER -

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