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Inhibition of Biofilm Formation of Staphylococcus Aureus Strains Through Zno/Zeolite Nanocomposite and Its Cytotoxicity Evaluation Publisher



Partoazar A1 ; Bideskan FR2 ; Partoazar M3 ; Talaei N4 ; Dallal MMS2, 5
Authors
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Authors Affiliations
  1. 1. Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Division of Microbiology, Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Geological Survey of Iran, Tehran, Iran
  4. 4. Department of Microbiology, North Tehran Branch, Islamic Azad University, Tehran, Iran
  5. 5. Department of Pathobiology, Food Microbiology Research Center, School of Public Health, Tehran University of Medical Sciences, P.O. Box: 6446-14155, Tehran, Iran

Source: BioNanoScience Published:2020


Abstract

Staphylococcus aureus biofilm formation through its binding to the surface of medical devices is a common and serious problem in clinic. This study aimed to evaluate the antibiofilm activity of zinc oxide containing zeolite nanocomposite (ZnO/ZeoNC) against standard and clinical strains of S. aureus and to assess its cytotoxicity on the human cell. The biofilm formation of S. aureus strains was exposed to ZnO/ZeoNC and then SEM imaging was provided for the morphology investigation of bacterial biofilm formation on polyethylene surface. Cell cytotoxicity of nanocomposite was assessed on HEp-2 cells during a 72-h exposure to concentrations of 44 μg/ml up to 350 μg/ml of Zn containing ZnO/ZeoNC. Results indicated that ZnO/ZeoNC had a significant (P < 0.05) antibiofilm action against S. aureus strains in sublethal dose of the nanocomposite. The influence of ZnO/ZeoNC on S. aureus biofilm revealed the elimination of the bacteria biofilm from the abiotic surface during 24-h cultivation. Furthermore, cell cytotoxicity of ZnO/ZeoNC exhibited an increasing trend that was dependent on the elevation of the zinc level. In conclusion, the current data suggest the usage of ZnO/ZeoNC in a safe and non-toxic manner against infectious due to staphylococcal colonization. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
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