Population Based Analysis of Twenty Year Incidence Trends of Pediatric Hodgkin Lymphoma in the United States Publisher Pubmed



Se Mousavi Seyed EHSAN ; M Najafi MORVARID ; A Aslani ARMIN ; H Ghasemi HOOMAAN ; Z Yekta ZAHRA ; Sa Nejadghaderi Seyed ARIA
Source: Scientific Reports Published:2025

Abstract

Hodgkin lymphoma (HL) is the most diagnosed cancer among young adults between the ages of 15 to 19 years. This study aims to update the HL incidence trends by age, sex, and race/ethnicity among children and adolescents in the United States (US) from 2000 to 2020. Surveillance, Epidemiology, and End Results (SEER) 22 data were utilized to estimate counts, age-adjusted incidence rates, and trends. HL patients were identified using the International Classification of Diseases for Oncology version 3. The annual percent change (APC) and average APC (AAPC) were computed using joinpoint regression. Between 2000 and 2019, the US documented a cumulative total of 10,007 of pediatric HL spanning various age categories. Classical HL comprised the majority (92.98%) of cases, predominantly affecting non-Hispanic Whites (53.28%) and individuals aged 15–19 years (66.35%). Trends in AAPCs showed no notable alterations. However, both incident cases and rates demonstrated a consistent rise with increasing age. While no significant changes were observed in the overall incidence trend of pediatric HL from 2000 to 2019, discrepancies persist among the results of different studies. Additional research is warranted to explore potential underlying factors that may influence these observed trends. © 2025 Elsevier B.V., All rights reserved.