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Increased Expression of the Receptor for Advanced Glycation End-Products (Rage) Is Associated With Advanced Breast Cancer Stage Publisher Pubmed



Nankali M1 ; Karimi J1 ; Goodarzi MT1 ; Saidijam M2 ; Khodadadi I1 ; Razavi ANE3 ; Rahimi F1
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Authors Affiliations
  1. 1. Department of Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Fahmideh Blvd., Hamadan, 6517838736, Iran
  2. 2. Department of Genetics and Molecular Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  3. 3. Iran National Tumor Bank, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Oncology Research and Treatment Published:2016


Abstract

Background: The receptor for advanced glycation end-products (RAGE) is a multiligand transmembrane receptor that is overexpressed in various pathological conditions including cancers. However, the expression pattern of RAGE in breast cancer tumors is still not completely clear. Methods: In this study, we investigated the expression levels of RAGE in 25 fresh-frozen breast cancer samples and corresponding noncancerous tissue samples collected from breast cancer patients, by real-time polymerase chain reaction (PCR). Additionally, we performed immunohistochemistry on breast cancer specimens. Results: The results indicate a high expression of the RAGE-encoding gene in the cancerous tissues. RAGE expression at the mRNA and protein levels was statistically significantly up-regulated in advanced-stage and triple-negative breast tumors and node-positive tissues compared with other tissues (p < 0.001). A significant association between RAGE expression and tumor size was observed (p = 0.029). Conclusions: Overexpression of RAGE in advanced-stage tumors may be a useful biomarker for diagnosis and the prediction of breast cancer progression. © 2016 S. Karger GmbH, Freiburg. All rights reserved.
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