Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Evaluation of Serum Hepcidin and Iron Levels in Patients With Pcos: A Case-Control Study Publisher Pubmed



Hossein Rashidi B1 ; Shams S1 ; Shariat M2 ; Kazemi Jaliseh H1 ; Mohebi M1 ; Haghollahi F1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Vali-e-Asr Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Endocrinological Investigation Published:2017


Abstract

Purpose: Polycystic ovary syndrome (PCOS) is the most common cause of chronic anovulation with a prevalence of 5–10% in women of reproductive age. The etiology of this disease is not well known, and hepcidin is one of the factors affecting the pathogenesis of the disease. The aim of this study was to evaluate plasma levels of hepcidin in patients with PCOS and its correlation with serum iron level. Methods: In this case-control study, plasma levels of hepcidin, IL-6, and ferritin using ELISA method and serum iron levels using a spectrophotometric method were tested on 56 women with PCOS (case group) and 41 healthy subjects (control group). The results were analyzed using t test, General Linear Model, Binary logistic regression, and linear regression tests. Results: The mean hepcidin levels were 1.97 ± 0.53 and 2.40 ± 0.25 pg/ml in the case and control groups, respectively. The t-test results showed significant difference between the two groups (p = 0.0001). The mean serum iron levels were 72.89 ± 28.97 and 70.62 ± 31.18 g/dl in the case and control groups, respectively. The t test analysis indicated no significant difference between the two groups. The serum ferritin and iron levels had no significant relation with serum hepcidin level in two groups. Conclusion: Despite the differences in the serum levels of hepcidin between the two groups, no significant relation was observed between serum iron levels and hepcidin level in this group of patients. This implies the need for more comprehensive studies on gene expression in hepcidin and iron pathways using real-time and Western techniques to investigate more precisely serum hepcidin level and its relationship with the factors mentioned. © 2017, Italian Society of Endocrinology (SIE).
Related Docs
1. Dual Role of Hepcidin in Response to Pathogens, Microbial Pathogenesis (2025)
2. Interplay Between Gut Microbiota and the Master Iron Regulator, Hepcidin, in the Pathogenesis of Liver Fibrosis, Pathogens and Disease (2024)
3. The Association Between Polycystic Ovary Syndrome, Obesity, and the Serum Concentration of Adipokines, Journal of Endocrinological Investigation (2017)
4. The Role of Melatonin in Polycystic Ovary Syndrome: A Review, International Journal of Reproductive BioMedicine (2019)
5. Quercetin and Polycystic Ovary Syndrome; Inflammation, Hormonal Parameters and Pregnancy Outcome: A Randomized Clinical Trial, American Journal of Reproductive Immunology (2023)
6. Astaxanthin Supplementation Impact on Insulin Resistance, Lipid Profile, Blood Pressure, and Oxidative Stress in Polycystic Ovary Syndrome Patients: A Triple-Blind Randomized Clinical Trial, Phytotherapy Research (2024)
Experts (# of related papers)
View all Related Experts
Fardin Amidi (2)
Nima Rezaei (1)