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Antioxidant-Rich Products As Protective Agents and Therapeutic Factors Against Chlorpyrifos Hepatotoxicity- a Review



Pourbabaki R1 ; Samiei S1 ; Khadem M1 ; Kalantari S1 ; Beigzadeh Z1 ; Shahtaheri SJ2
Authors
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Authors Affiliations
  1. 1. Department of Occupational Health Engineering, School of Public Health, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Department of Occupational Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Iran Occupational Health Published:2021

Abstract

Background and aims: Recently, the growing concerns of the scientific community has been focused on the threat to health caused by environmental pollutants, including pesticides such as Chlorpyrifos (CPF). Therefore, finding effective ways to treat and prevent the unfavorable health effects of being exposed to such pllutants is needed. Particularly, promising for CPF, and thus arousing the greatest interest, is the possibility of using various ingredients that are present in plants, including mainly polyphenol compounds. As the liver is one of the organs that protects us against this pesticide, any disturbance in the proper functioning of this organ could lead to serious consequences for health. Thus, the aim of the present review was to discuss the possibility of using polyphenol-rich food products as a strategy for the protection against this xenobiotic hepatotoxicity and treatment of this pesticide-induced liver damage. Methods: A comprehensive search was performed in various databases, using specific keywords such as biologically active compounds, antioxidants, Chlorpyrifos/CPF, environmental exposure, health effects, hepatotoxicity, liver damage, mechanisms of Chlorpyrifos/CPF action, oxidative stress, preventive strategies, polyphenols, protection, risk for health, and treatment. Results and Conclusions: Due to the ability and the strong antioxidative potential of polyphenols, as well as their abundance in dietary products, it seems to be of high importance to consider the possibility of using polyphenols, as potential preventive and therapeutic agents against CPF hepatotoxicity, determined by its strong pro-oxidative properties. Although most of the data on the effectiveness of polyphenols, comes from animal testing, the fact that some of them are derived from experimental models reflecting human exposure to this pesticide, allows us to assume that some polyphenol food products may have promising protective effects against CPF hepatotoxicity in humans. © 2021 Iran University of Medical Sciences. All rights reserved.
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