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Arglabin Could Target Inflammasome-Induced Ards and Cytokine Storm Associated With Covid-19 Publisher Pubmed



Manayi A1 ; Nabavi SM2 ; Khayatkashani M3 ; Habtemariam S4 ; Khayat Kashani HR5
Authors
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Authors Affiliations
  1. 1. Faculty of Pharmacy, Medicinal Plants Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  3. 3. School of Iranian Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Pharmacognosy Research Laboratories and Herbal Analysis Services, University of Greenwich, Central Avenue, Chatham-Maritime, United Kingdom
  5. 5. Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Madani Street, Tehran, Iran

Source: Molecular Biology Reports Published:2021


Abstract

Arglabin (l(R),10(S)-epoxy-5(S),5(S),7(S)-guaia-3(4),ll(13)-dien-6,12-olide), is a natural sesquiterpene γ-lactone which was first isolated from Artemisia glabella. The compound has been shown to possess anti-inflammatory activity through inhibition of the NLR Family pyrin domain-containing 3 (NLRP3) inflammasome and production of proinflammatory cytokines including interleukin (IL)-1β and IL-18. A more hydrophilic derivative of the compound also exhibited antitumor activity in the breast, colon, ovarian, and lung cancer. Some other synthetic derivatives of the compound have also been synthesized with antitumor, cytotoxic, antibacterial, and antifungal activities. Since both NLRP3 inflammasome and cytokine storm are associated with the pathogenesis of COVID-19 and its lethality, compounds like arglabin might have therapeutic potential to attenuate the inflammasome-induced acute respiratory distress syndrome and/or the cytokine storm associated with COVID-19. © 2021, Crown.
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