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Naturally Occurring Anti-P1 With High Thermal Amplitude Complicating Abo Blood Grouping Publisher



S Ferdowsi SHIRIN ; S Mohammadi SAEED ; M Ahmadnezhad MOHARRAM ; F Herfat FAHIMEH ; A Rezvani AZITA ; P Eshghi PEYMAN ; A Oodi AREZOO
Authors

Source: Asian Journal of Transfusion Science Published:2024


Abstract

Anti-P1 is immunoglobulin M type and occurs naturally; it is often detected as a weak- and cold-reactive antibody. However, in rare cases, it is reactive at 37°C or shows hemolytic transfusion reactions. The presence of high thermal amplitude of anti-P1 cannot be ignored and requires cross-match compatible red blood cells for transfusion. In the present study, we report three cases with ABO discrepancy due to anti-P1 that was identified as a cold-reacting antibody with high thermal amplitude. © 2024 Elsevier B.V., All rights reserved.