The Effect of Oligopin Supplementation on Hormonal and Metabolic Profiles in the Polycystic Ovary Syndrome: A Randomized Controlled Trial

The Effect of Oligopin Supplementation on Hormonal and Metabolic Profiles in the Polycystic Ovary Syndrome: A Randomized Controlled Trial Publisher

Qorbani M^{1, 2} ; Sanginabadi M³ ; Mohajeritehrani MR⁴ ; Karimi S⁵ ; Gerami H⁴ ; Mahdavigorabi A^{1, 6} ; Shirzad N^{4, 7} ; Samadi M³ ; Baygi F⁸ ; Hosseini S^{4, 9} ; Mansour A^{4, 5}

Show Affiliations

1. Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran
2. Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran
3. Radiology Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
4. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Science, Tehran, Iran
6. Social Determinants of Health Research Center, Alborz University of Medical Sciences, Karaj, Iran
7. Department of Endocrinology, Vali-Asr Hospital, Endocrinology and Metabolism Research Center, Imam Khomeini Complex Hospital, Tehran University of Medical Sciences, Tehran, Iran
8. Centre of Maritime Health and Society, Department of Public Health, University of Southern Denmark, Esbjerg, Denmark
9. Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

Source: Frontiers in Endocrinology Published:2020

Abstract

Background: A double blind clinical trial was performed to evaluate whether the polycystic ovary syndrome (PCOS)-specific serum markers and metabolic parameters would change in the women with PCOS during the three-month administration of oligopin. Methods: In this double-blind multicenter trial, we randomly assigned 80 PCOS women, based on a 1:1 ratio, to receive oligopin (n= 40) or maltodextrin as placebo (n = 40) for up to 3 months. As PCOS-specific outcomes, we investigated the changes in testosterone, sex hormone binding globulin (SHBG), free androgen index (FAI), dehydroepiandrosterone (DHEA), follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Secondary end points were metabolic (fasting glycaemia, hemoglobin A1c (HbA1c), lipids, insulin resistance (HOMA-IR)), anthropometrics parameters and blood pressure from the baseline to the end of treatment. We investigated serum transaminase, alkaline phosphatase (ALP), creatinine (Cr) and blood urea nitrogen (BUN) levels as hepatic and kidney outcomes, respectively. Results: The first participant was enrolled on April 18, 2018, and the last study visit took place on May 14, 2019. PCOS-specific serum parameters did not change during the three-month administration of oligopin (p > 0.05), except for a small increase in the FSH levels (p=0.03). Oligopin neither changed the metabolic profile nor the anthropometric parameters or blood pressure. ALP levels was significantly increased in placebo group, as compared with oligopin (p=0.01). Conclusion: Oligopin supplementation does not seem to be exerting a beneficial effect on both hormonal and metabolic parameters in the women with PCOS. Clinical Trial Registration: www.irct.ir, identifier IRCT20140406017139N3. © Copyright © 2020 Qorbani, Sanginabadi, Mohajeri-Tehrani, Karimi, Gerami, Mahdavi-Gorabi, Shirzad, Samadi, Baygi, Hosseini and Mansour.

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Mohammad Reza Mohajeri Tehrani (5)

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Style	Citing Format
MLA	Qorbani M, et al.. "The Effect of Oligopin Supplementation on Hormonal and Metabolic Profiles in the Polycystic Ovary Syndrome: A Randomized Controlled Trial." Frontiers in Endocrinology, vol. 11, no. , 2020, pp. -.
APA	Qorbani M, Sanginabadi M, Mohajeritehrani MR, Karimi S, Gerami H, Mahdavigorabi A, Shirzad N, Samadi M, Baygi F, Hosseini S, Mansour A (2020). The Effect of Oligopin Supplementation on Hormonal and Metabolic Profiles in the Polycystic Ovary Syndrome: A Randomized Controlled Trial. Frontiers in Endocrinology, 11(), -.
Chicago	Qorbani M, Sanginabadi M, Mohajeritehrani MR, Karimi S, Gerami H, Mahdavigorabi A, Shirzad N, et al.. "The Effect of Oligopin Supplementation on Hormonal and Metabolic Profiles in the Polycystic Ovary Syndrome: A Randomized Controlled Trial." Frontiers in Endocrinology 11, no. (2020): -.
Harvard	Qorbani M et al. (2020) 'The Effect of Oligopin Supplementation on Hormonal and Metabolic Profiles in the Polycystic Ovary Syndrome: A Randomized Controlled Trial', Frontiers in Endocrinology, 11(), pp. -.
Vancouver	Qorbani M, Sanginabadi M, Mohajeritehrani MR, Karimi S, Gerami H, Mahdavigorabi A, et al.. The Effect of Oligopin Supplementation on Hormonal and Metabolic Profiles in the Polycystic Ovary Syndrome: A Randomized Controlled Trial. Frontiers in Endocrinology. 2020;11():-.
BibTex	@article{ author = {Qorbani M and Sanginabadi M and Mohajeritehrani MR and Karimi S and Gerami H and Mahdavigorabi A and Shirzad N and Samadi M and Baygi F and Hosseini S and Mansour A}, title = {The Effect of Oligopin Supplementation on Hormonal and Metabolic Profiles in the Polycystic Ovary Syndrome: A Randomized Controlled Trial}, journal = {Frontiers in Endocrinology}, volume = {11}, number = {}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Qorbani M AU - Sanginabadi M AU - Mohajeritehrani MR AU - Karimi S AU - Gerami H AU - Mahdavigorabi A AU - Shirzad N AU - Samadi M AU - Baygi F AU - Hosseini S AU - Mansour A TI - The Effect of Oligopin Supplementation on Hormonal and Metabolic Profiles in the Polycystic Ovary Syndrome: A Randomized Controlled Trial JO - Frontiers in Endocrinology VL - 11 IS - SP - EP - PY - 2020 ER -

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