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Biocompatibility of Portland Cement Modified With Titanium Oxide and Calcium Chloride in a Rat Model Publisher



Hoshyari N1 ; Labbaf H2 ; Naderi NJ3 ; Kazemi A2 ; Bastami F4 ; Koopaei M5
Authors
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Authors Affiliations
  1. 1. Endodontic Department, Dental School, Mazandaran University of Medical Sciences, Sari, Iran
  2. 2. Endodontic Department, Dental School, Shahed University, Tehran, Iran
  3. 3. Oral Pathology Department, Dental School, Shahed University, Tehran, Iran
  4. 4. Research Institute of Dental Sciences, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Oral Medicine Department, Dental School, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Endodontic Journal Published:2016


Abstract

Introduction: The aim of the present study was to evaluate the biocompatibility of two modified formulations of Portland cement (PC) mixed with titanium oxide or both titanium oxide and calcium chloride. Methods and Materials: Polyethylene tubes were filled with each of modified PCs or Angelus MTA as a control; the tubes were implanted in 28 Wistar rats, subcutaneously. One tube was left empty as a negative control in each rat. Histologic samples were taken after 7, 15, 30 and 60 days. Sections were assessed histologically for inflammatory responses and presence of fibrous capsule and granulation tissue formation. Data were analyzed using the Fisher’s exact and Kruskal-Wallis tests. Result: PC mixed with titanium oxide showed the highest mean scores of inflammation compared with others. There was no statistically significant difference in the mean inflammatory grades between all groups in each understudy times. Conclusion: The results showed favorable biocompatibility of these modified PC mixed with calcium chloride and titanium oxide. © 2016, Iranian Association of Endodontics. All Rights Reserved.
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