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Association of Haptoglobin and Natural Resistance-Associated Macrophage Protein 1 Alleles With Heme-Consuming Periodontal Pathogens in Chronic Periodontitis and Peri-Implantitis: A Pilot Study Publisher



Kadkhodazadeh M1 ; Ebadian AR2 ; Tabari ZA3 ; Amid R4 ; Moscowchi A4
Authors
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Authors Affiliations
  1. 1. Dental Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Private Practice, Tehran, Iran
  3. 3. Department of periodontics, School of Dentistry, Tehran University of Medical Sciences, International Campus, Tehran, Iran
  4. 4. Department of Periodontics, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Journal of Advanced Periodontology and Implant Dentistry Published:2020


Abstract

Background. This study aimed to assess the association of haptoglobin (HP) and natural resistanceassociated macrophage protein 1 (NRAMP1) alleles with the presence of heme-consuming periodontal pathogens in a group of Iranian patients with chronic periodontitis and peri-implantitis. Methods. This cross-sectional study evaluated 69 eligible chronic periodontitis and peri-implantitis patients selected from Shahid Beheshti Dental School. The periodontally diseased individuals had at least three teeth with clinical attachment loss of ≥3 mm and a probing pocket depth (PPD) of ≥3 mm in at least two quadrants. Peri-implant PPD of at least one site was ≥5 mm with or without suppuration and bleeding on probing. A plaque index of >%20 and a radiographic crestal bone loss was present in at least one site around the implant. The paper point method was used for sampling from the deepest periodontal/peri-implant pocket of each tooth or implant for the DNA checkerboard hybridization technique. Statistical analyses were performed with PASW Statistics 18.0. The variables were presented as absolute and relative frequencies (%). Results. An Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans) score of 2–1 was 5.8 times more frequent in HP 2, rs1723540 G, and rs2276631 G alleles. A Porphyromonas gingivalis (P. gingivalis) score of 2–1 was 4.8 times more common in the subjects carrying HP 2, rs1723540 G, and rs2276631 G alleles compared with HP 1, rs1723540 A, and rs2276631 A alleles. Conclusion. Within the limitations of this study, it seems that there was a relationship between HP and NRAMP1 allele frequencies and the presence of heme-consuming periodontal pathogens in the Iranian patients with chronic periodontitis and peri-implantitis evaluated in the present study. © 2020 The Author(s).
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