Laser Induced Fluorescence Spectroscopy of Chemo-Drugs As Biocompatible Fluorophores: Irinotecan, Gemcitabine and Navelbine

Laser Induced Fluorescence Spectroscopy of Chemo-Drugs As Biocompatible Fluorophores: Irinotecan, Gemcitabine and Navelbine Publisher

Hosseini Motlagh NS¹ ; Parvin P¹ ; Ghasemi F¹ ; Atyabi F² ; Jelvani S³ ; Abolhosseini S³

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1. Physics Department, Amirkabir University of Technology, Tehran, 15875-4413, Iran
2. Nano Medicine and Biomaterial Lab, Pharmaceutics Department, Faculty of Pharmacy, Tehran University of Medical Sciences, PO Box 14176-14411, Tehran, Iran
3. Laser and Optics Research School, Nuclear, Science and Technology Research Institute (NSTRI), Tehran, Iran

Source: Laser Physics Letters Published:2016

Abstract

The fluorescence nature of chemo-drugs is useful for simultaneous cancer diagnosis and therapy. Here, the laser induced fluorescence (LIF) properties of irinotecan, gemcitabine and navelbine are extensively investigated. The UV photons provoke the desired transitions of the several chemo-drugs by virtue of the XeCl laser at 308 nm. It is shown that LIF spectra are strongly dependent on the fluorophore concentration, while no spectral shift is measured for irinotecan, gemcitabine and navelbine because of a large Stokes shift. On the other hand, doxorubicin is characterized by a large overlapping between absorption and emission spectra giving rise to a sensible red shift. The fluorescence extinction α and self-quenching k coefficients as well as the quantum yield η f of those chemo-drugs are determined accordingly. In fact, irinotecan shows the highest quantum efficiency among the chemo-drugs of interest. © 2016 Astro Ltd.

Style	Citing Format
MLA	Hosseini Motlagh NS, et al.. "Laser Induced Fluorescence Spectroscopy of Chemo-Drugs As Biocompatible Fluorophores: Irinotecan, Gemcitabine and Navelbine." Laser Physics Letters, vol. 13, no. 7, 2016, pp. -.
APA	Hosseini Motlagh NS, Parvin P, Ghasemi F, Atyabi F, Jelvani S, Abolhosseini S (2016). Laser Induced Fluorescence Spectroscopy of Chemo-Drugs As Biocompatible Fluorophores: Irinotecan, Gemcitabine and Navelbine. Laser Physics Letters, 13(7), -.
Chicago	Hosseini Motlagh NS, Parvin P, Ghasemi F, Atyabi F, Jelvani S, Abolhosseini S. "Laser Induced Fluorescence Spectroscopy of Chemo-Drugs As Biocompatible Fluorophores: Irinotecan, Gemcitabine and Navelbine." Laser Physics Letters 13, no. 7 (2016): -.
Harvard	Hosseini Motlagh NS et al. (2016) 'Laser Induced Fluorescence Spectroscopy of Chemo-Drugs As Biocompatible Fluorophores: Irinotecan, Gemcitabine and Navelbine', Laser Physics Letters, 13(7), pp. -.
Vancouver	Hosseini Motlagh NS, Parvin P, Ghasemi F, Atyabi F, Jelvani S, Abolhosseini S. Laser Induced Fluorescence Spectroscopy of Chemo-Drugs As Biocompatible Fluorophores: Irinotecan, Gemcitabine and Navelbine. Laser Physics Letters. 2016;13(7):-.
BibTex	@article{ author = {Hosseini Motlagh NS and Parvin P and Ghasemi F and Atyabi F and Jelvani S and Abolhosseini S}, title = {Laser Induced Fluorescence Spectroscopy of Chemo-Drugs As Biocompatible Fluorophores: Irinotecan, Gemcitabine and Navelbine}, journal = {Laser Physics Letters}, volume = {13}, number = {7}, pages = {-}, year = {2016} }
RIS	TY - JOUR AU - Hosseini Motlagh NS AU - Parvin P AU - Ghasemi F AU - Atyabi F AU - Jelvani S AU - Abolhosseini S TI - Laser Induced Fluorescence Spectroscopy of Chemo-Drugs As Biocompatible Fluorophores: Irinotecan, Gemcitabine and Navelbine JO - Laser Physics Letters VL - 13 IS - 7 SP - EP - PY - 2016 ER -

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