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Tumefactive Multiple Sclerosis Variants: Report of Two Cases of Schilder and Balo Diseases



Ashrafi MR1 ; Tavasoli AR1 ; Alizadeh H2 ; Zare Noghabi J3 ; Parvaneh N4
Authors
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Authors Affiliations
  1. 1. Department of Pediatrics, Division of Pediatric Neurology, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pediatrics, Division of Pediatric Radiology, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pediatrics, Ardabil University of Medical Sciences, Ardabil, Iran
  4. 4. Department of Pediatrics, Division of Allergy and Clinical Immunology, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Child Neurology Published:2017

Abstract

A tumefactive lesion of central nervous system (CNS) is defined as a mass-like lesion with a size greater than 2 cm in brain detected by magnetic resonance imaging (MRI). Neuroimaging may help to distinguish the nature of a tumefactive lesion and therefore, can prevent an unnecessary brain biopsy. Here we emphasized on determining the nature of a CNS tumefactive lesions with the help of MRI and more explanations about demyelinating lesions with focus on Schilder and Balo diseases as two multiple sclerosis variants. We have reported here two boys of 10 and 8 years of age respectively of multiple sclerosis (MS) variants who presented with acute neurologic complications to our hospital as one of the two referral children hospital in Tehran, Iran. Tumefactive demyelinating lesions can be considered a separate entity that itself can contain Schilder disease, Balo disease, some cases of acute disseminated encephalomyelitis (ADEM) or classic MS. MRI can help to establish a diagnosis of a tumefactive lesion and to differentiate among different underlying etiologies. © 2017, Iranian Child Neurology Society. All rights reserved.