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A Case Report on Pulmonary Metastasis of Giant Cell Tumor Mimicking Arteriovenous Malformation Publisher



Yazdi NA1 ; Parviz S1 ; Delazar S1 ; Azadnajafabad S1 ; Aleseidi S2 ; Saffar H3 ; Sadighi N1
Authors
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Authors Affiliations
  1. 1. Department of Radiology, School of Medicine, Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Imam Khomeini Hospital complex (IKHC), Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Heumatology and Internal Medicine, Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pathology, Anatomical and Clinical Pathology, Cancer Institute, Imam Khomeini Hospital complex (IKHC), Tehran University of Medical Sciences, Tehran, Iran

Source: Radiology Case Reports Published:2024


Abstract

Giant cell tumor (GCT) is typically a benign tumor of the skeletal system that mainly presents with bone pain. Pulmonary metastasis is one of the distant presentations of GCT in patients who have previously undergone surgical resection of the tumor. Among the various presentations of pulmonary metastasis in GCT, lesions with arteriovenous malformation (AVM) features are rare and have only been reported in a few cases. In this case report, we present the case of a 29-year-old female patient who had previously undergone surgical resection of a GCT in her right lower extremity 4 years ago. The patient was referred to us with progressive dyspnea, and a lesion resembling an AVM was found during radiologic evaluation using chest computed tomography. Pathologic evaluation of the lesion after biopsy revealed that it was a metastasis of GCT presenting with vascular-like features in the lung. This study reports on a very rare occurrence of GCT pulmonary metastasis with an AVM appearance on imaging, highlighting the clinical importance of atypical presentations of pulmonary metastasis in patients with a history of GCT. Appropriate and timely screening and management of such lesions may prevent adverse outcomes such as massive hemorrhage and deterioration of lung function. © 2023