Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Can Hdl Cholesterol Be Replaced by Paraoxonase 1 Activity in the Prediction of Severe Coronary Artery Disease in Patients With Type 2 Diabetes? Publisher Pubmed



Mahrooz A1, 2, 3, 4 ; Khosraviasrami OF4 ; Alizadeh A5 ; Mohmmadi N6 ; Bagheri A2, 4 ; Kashi Z3 ; Bahar A3 ; Nosrati M4 ; Mackness M7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  2. 2. Immunogenetics Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  3. 3. Diabetes Research Center, Imam Teaching Hospital, Mazandaran University of Medical Sciences, Sari, Iran
  4. 4. Department of Clinical Biochemistry and Medical Genetics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  5. 5. Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
  6. 6. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Division of Cardiovascular Sciences, University of Manchester, Manchester, United Kingdom

Source: Nutrition# Metabolism and Cardiovascular Diseases Published:2023


Abstract

Background and aims: Novel biomarkers are required to improve cardiovascular disease prediction in patients with type 2 diabetes (T2D) as a high-risk population. This study was conducted to examine whether coronary artery disease (CAD) risk assessment can be improved by substituting high-density lipoprotein (HDL)-bound paraoxonase 1 (PON1) activity for HDL cholesterol (HDL-C) concentration in patients with T2D. Methods and results: In this study, we studied 139 patients with T2D (mean age 64.12 ± 8.17 years) who underwent coronary angiographic examination. The initial rate of substrate hydrolysis was spectrophotometrically assayed in kinetic mode for measuring PON1 activity. Receiver operating characteristic (ROC) graphs are created by plotting true positivity versus false positivity. In patients with HbA1c ≥ 7%, PON1 (AUC = 0.7, p = 0.029) and nonHDL-C/PON1 (AUC = 0.75, p = 0.013) were significantly more capable of differentiating patients with CAD from those without CAD compared to HDL-C and nonHDL-C/HDL-C. Also, the predictive power of PON1 (AUC = 0.64, p = 0.029) and nonHDL-C/PON1 (AUC = 0.71, p = 0.004) were significantly higher in comparison with HDL-C and nonHDL-C/HDL-C for CAD characterization in patients aged ≥50 years. Moreover, PON1 and nonHDL-C/PON1 are associated with the incidence of CAD with an AUC of 0.7 (p = 0.026) and AUC of 0.64 (p = 0.087), respectively, among subjects with low HDL-C. Conclusion: PON1 and the ratio of nonHDL-C/PON1 significantly improve the prediction of severe CAD in T2D patients and in patients with HbA1c ≥ 7%, age ≥50 years, or low HDL-C. PON1 activity and lipid ratios using this enzyme may be valuable as substitutes of HDL-C for increasing clinical efficacies in cardiovascular risk assessment. © 2023 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University
Related Docs
1. Bmi Modifies Hdl-C Effects on Coronary Artery Bypass Grafting Outcomes, Lipids in Health and Disease (2022)
2. A-Esterase, Encyclopedia of Toxicology# Fourth Edition: Volume 1-9 (2023)
3. Sex-Based Association Between High-Density Lipoprotein Cholesterol and Adverse Outcomes After Coronary Artery Bypass Grafting, BMC Cardiovascular Disorders (2024)
4. Clinical Utility of Lipid Ratios As Potential Predictors of Metabolic Syndrome Among the Elderly Population: Birjand Longitudinal Aging Study (Blas), BMC Geriatrics (2023)
Experts (# of related papers)
View all Related Experts
Soheil Mansourian (2)
Masih Tajdini (2)