Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Protective and Pathological Roles of Regulatory Immune Cells in Human Cytomegalovirus Infection Following Hematopoietic Stem Cell Transplantation Publisher Pubmed



Namdari H1 ; Hosseini M2 ; Yazdanifar M3 ; Farajifard H1 ; Parvizpour F1 ; Karamigolbaghi M1 ; Hamidieh AA2 ; Rezaei F4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Iranian Tissue Bank and Research Center, Gene, Cell and Tissue Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Pediatric Cell and Gene Therapy Research Center, Gene, Cell and Tissue Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Pediatrics, Stem Cell Transplantation and Regenerative Medicine, Stanford University School of Medicine, Palo Alto, CA, United States
  4. 4. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

Source: Reviews in Medical Virology Published:2022


Abstract

Human cytomegalovirus (HCMV) is ubiquitously prevalent. Immune system in healthy individuals is capable of controlling HCMV infection; however, HCMV can be life-threatening for immunocompromised individuals, such as transplant recipients. Both innate and adaptive immune systems are critically involved in the HCMV infection. Recent studies have indicated that regulatory immune cells which play essential roles in maintaining a healthy immune environment are closely related to immune response in HCMV infection. However, the exact role of regulatory immune cells in immune regulation and homoeostasis during the battle between HCMV and host still requires further research. In this review, we highlight the protective and pathological roles of regulatory immune cells in HCMV infection following hematopoietic stem cell transplantation (HSCT). © 2021 John Wiley & Sons Ltd.
Related Docs
View other Related Docs
1. Co-Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells With Hematopoietic Stem Cells Does Not Improve Transplantation Outcome in Class Iii Beta-Thalassemia Major: A Prospective Cohort Study With Long-Term Follow-Up, Pediatric Transplantation (2021)
2. Cell Therapy in Transplantation: A Comprehensive Review of the Current Applications of Cell Therapy in Transplant Patients With the Focus on Tregs, Car Tregs, and Mesenchymal Stem Cells, International Immunopharmacology (2021)
3. Overview and Recent Advances of Regulatory T Cell Therapy in Solid Organ Transplantation, Iranian Journal of Kidney Diseases (2021)
4. Mesenchymal Stem Cell Transplantation in Newly Diagnosed Type-1 Diabetes Patients: A Phase I/Ii Randomized Placebo-Controlled Clinical Trial, Stem Cell Research and Therapy (2022)
5. Cytomegalovirus and Its Role in Congenital Infection: A Narrative-Review Study, Iranian Journal of Obstetrics# Gynecology and Infertility (2020)
6. Ankylosing Spondylitis and Mesenchymal Stromal/Stem Cell Therapy: A New Therapeutic Approach, Biomedicine and Pharmacotherapy (2019)
7. Immune Regulatory Network in Successful Pregnancy and Reproductive Failures, Biomedicine and Pharmacotherapy (2017)
8. Mesenchymal Stromal/Stem Cells (Mscs) and Msc-Derived Extracellular Vesicles in Covid-19-Induced Ards: Mechanisms of Action, Research Progress, Challenges, and Opportunities, International Immunopharmacology (2021)
Experts (# of related papers)
View all Related Experts
Ali Akbar Amirzargar (2)
Sara Assadiasl (2)
Other Related Docs
9. Challenges in Mesenchymal Stromal Cell-Based Therapies, Current Stem Cell Research and Therapy (2023)
10. Human Cytomegalovirus Infection Enhances 5‑Lipoxygenase and Cycloxygenase‑2 Expression in Colorectal Cancer, International Journal of Oncology (2023)
11. The Role of Myeloid-Derived Suppressor Cells in Lung Cancer and Targeted Immunotherapies, Expert Review of Anticancer Therapy (2022)
12. Mesenchymal Stromal Cells; a New Horizon in Regenerative Medicine, Journal of Cellular Physiology (2020)
13. Challenges in Osteoarthritis Treatment, Tissue and Cell (2023)
14. Isolation and in Vitro Expansion of Regulatory T Cells From Β-Thalassemia Major Kids and in Vitro Evaluation of Their Plasticity and Inhibitory Effects in the Presence of Pro-Inflammatory Cytokines, International Archives of Allergy and Immunology (2023)
15. Multipotent Stem Cell and Current Application, Acta Medica Iranica (2017)
16. Covid-19 Immunotherapy: Treatment Based on the Immune Cell-Mediated Approaches, International Immunopharmacology (2022)
17. The Promising Approach of Mscs Therapy for Covid-19 Treatment, Cell and Tissue Banking (2023)
18. Identification, Isolation, and Functional Assay of Regulatory T Cells, Immunological Investigations (2016)
19. The Paths and Challenges of “Off-The-Shelf” Car-T Cell Therapy: An Overview of Clinical Trials, Biomedicine and Pharmacotherapy (2023)
20. Mesenchymal Stem/Stromal Cells As a Valuable Source for the Treatment of Immune-Mediated Disorders, Stem Cell Research and Therapy (2021)