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Evaluation of the Efficacy, Safety and Satisfaction Rates of Platelet-Rich Plasma, Non-Cross-Linked Hyaluronic Acid and the Combination of Platelet-Rich Plasma and Non-Cross-Linked Hyaluronic Acid in Patients With Burn Scars Treated With Fractional Co2 Laser: A Randomized Controlled Clinical Trial Publisher Pubmed



Roohaninasab M1, 2 ; Jafarzadeh A1, 2 ; Sadeghzadehbazargan A1, 2 ; Zare S2, 3, 4, 5 ; Nouri M2 ; Nilforoushzadeh MA2, 6 ; Behrangi E1, 2
Authors
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Authors Affiliations
  1. 1. Department of Dermatology, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran
  2. 2. Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Stem Cell and Regenerative Medicine Institute, Sharif University of Technology, Tehran, Iran
  5. 5. Department of Mechanical Engineering, Sharif University of Technology, Tehran, Iran
  6. 6. Skin Repair Research Center, Jordan Dermatology and Hair Transplantation Center, Tehran, Iran

Source: International Wound Journal Published:2024


Abstract

Skin scarring can result from burns, injuries, stretch marks and acne, leading to cosmetic and functional difficulties. Treatments for burn scars encompass a range of options, such as lasers, corticosteroid injections, surgery and regenerative techniques such as platelet-rich plasma (PRP). Hyaluronic acid-based products offer skin hydration and shield against aging effects. A study is being conducted to evaluate how effective PRP injection, hyaluronic acid and their combination improve burn scars and their effects on quality of life and potential disabilities. In our study, PRP and non-cross-linked hyaluronic acid treatments were compared in 10 individuals with burn scars between 2022 and 2023. Patients received CO2 fractional laser treatment followed by injections in scar areas. Evaluations included the Vancouver scar scale (VSS), biometric assessments, ultrasounds and satisfaction ratings. Two therapy sessions were conducted at 1-month interval, and assessments were done before treatment, 1 month after the first session, and 3 months after the first session. Biometric assessments showed significant improvements in various parameters (tewametry, corneometry, erythema index, melanin index, cutometry, thickness and density) in the intervention groups compared to the placebo group (p <0.05). PRP-non-cross-linked hyaluronic acid, PRP and non-cross-linked hyaluronic acid treatments exhibited the best clinical responses with significant differences between groups (p <0.05). Dermal thickness did not show significant improvement during treatment sessions, and changes among subjects were not significantly different. The colorimetry parameter improved in all groups except the placebo group, with no significant difference between intervention groups. The VSS significantly decreased in all treatment groups except the placebo group. PRP, non-cross-linked hyaluronic acid and especially the combination of these two treatment options are very effective in treating burn scars. © 2024 The Author(s). International Wound Journal published by Medicalhelplines.com Inc and John Wiley & Sons Ltd.