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The Effect of Vitamin D Supplements on Clinical and Para-Clinical Outcomes in Patients With Multiple Sclerosis: Protocol for a Systematic Review Publisher



Ghajarzadeh M1 ; Keshtkar AA2 ; Azimi A3 ; Sahraian MA3 ; Mohammadifar M4 ; Ramagopalan SV5
Authors
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Authors Affiliations
  1. 1. Universal Council of Epidemiology, Universal Scientific Education and Research Network, Tehran University of Medical Sciences Imam Khomeini Hospital, Children's Medical Center, Keshavarz Blvd No 62, Islamic, 1468763841, Iran
  2. 2. Department of Health Sciences Education Development, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Radiology, Zanjan University of Medical Sciences, Zanjan, Iran
  5. 5. United Kingdom, Bristol-Myers Squibb, Uxbridge, United Kingdom

Source: JMIR Research Protocols Published:2019


Abstract

Background: Multiple sclerosis (MS) is an inflammatory disease, which has a wide range of effects on patients. There are controversies regarding the role of Vitamin D in clinical and laboratory improvements in MS patients. Objective: The aim of this systematic review protocol is to evaluate the efficacy of Vitamin D supplements on relapse rate, gadolinium-enhancing lesions of magnetic resonance imaging (MRI), and cytokine profiles. Methods: We will search PubMed, Scopus, EMBASE, CINAHL, Web of Science, Ovid, ProQuest, American College of Physicians Journal Club database, Health Technology Assessment Database (The Cochrane Collaboration), and National Health System Economic Evaluation Database (The Cochrane Collaboration) and gray literature including reference of included studies and conference abstracts. Clinical trials reporting the effect of any doses of Vitamin D on relapse rate, gadolinium-enhancing lesions of MRI, and cytokine profiles will be included. In total, 2 independent researchers will independently assess the studies, extract data, and evaluate the quality of primary studies. Results: This systematic review was started in September 2017 and the process is continuing. The included articles are evaluated and researchers are going to extract the data. Conclusions: To our knowledge, this will be the first comprehensive systematic review aiming to assess the effect of Vitamin D supplements on clinical and para-clinical outcomes in patients with multiple sclerosis. © 2019 Journal of Medical Internet Research. All rights reserved.
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