Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Protective Effects of Cerium Oxide and Yttrium Oxide Nanoparticles on Reduction of Oxidative Stress Induced by Sub-Acute Exposure to Diazinon in the Rat Pancreas Publisher Pubmed



Khaksar MR1 ; Rahimifard M2 ; Baeeri M2 ; Maqbool F2, 3 ; Navaeinigjeh M2, 4 ; Hassani S2 ; Moeininodeh S2 ; Kebriaeezadeh A2 ; Abdollahi M2, 3, 4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Occupational Health, Faculty of Health, Qom University of Medical Sciences, Qom, Iran
  2. 2. Toxicology and Diseases Group, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Tehran University of Medical Sciences, International Campus, (TUMS-IC), Tehran, 1417614411, Iran
  4. 4. Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Trace Elements in Medicine and Biology Published:2017


Abstract

Diazinon is a kind of organophosphorus (OP) compound that is broadly used against different species of insects and pests. Oxidative stress can occur at very early stages of diazinon exposure and the pancreas is one of the main target organs for toxicity by diazinon. The aim of this study was to evaluate the protective effects of cerium oxide nanoparticles (CeO2 NPs) and yttrium oxide nanoparticles (Y2O3 NPs) against the pancreatic damage from sub-acute exposure of diazinon. Diazinon at a dose of 70 mg/kg/day was given through gavage to rats once a day. Along with diazinon, trace amounts of CeO2 NPs and Y2O3 NPs (35 mg/kg and 45 mg/kg per day, respectively) were administered by intraperitoneal injection once a day for 2 weeks. Animals weight and blood glucose were measured during the treatment, and oxidative stress biomarkers, diabetes physiology, function and viability of cells were investigated at the end of the treatment in serum and pancreas tissues. Apoptosis of islets was examined by the flow cytometry. The high blood glucose level and significant weight loss resulting from diazinon were modified as a result of the application of the NPs. A significant recovery in oxidative stress markers, pro-insulin, insulin, C-peptide, adenosine diphosphate/adenosine triphosphate (ATP/ADP) ratio, caspase-3 and -9 activities and apoptosis–necrosis in the islets was observed. In conclusion, administration of CeO2 NPs or Y2O3 NPs only or their combination with suitable and defined dose will help to overcome the consequences from oxidant agents. © 2017 Elsevier GmbH
Related Docs
View other Related Docs
1. Alteration of Hepatocellular Antioxidant Gene Expression Pattern and Biomarkers of Oxidative Damage in Diazinon-Induced Acute Toxicity in Wistar Rat: A Time–Course Mechanistic Study, EXCLI Journal (2018)
2. Biochemical and Molecular Evidence on the Role of Vaspin in Early Detection of the Insulin Resistance in a Rat Model of High-Fat Diet and Use of Diazinon, Toxicology (2019)
3. Pesticides: An Update of Human Exposure and Toxicity, Archives of Toxicology (2017)
4. Blockage of Both the Extrinsic and Intrinsic Pathways of Diazinon-Induced Apoptosis in Patu Cells by Magnesium Oxide and Selenium Nanoparticles, International Journal of Nanomedicine (2016)
5. An Electrocardiographic, Molecular and Biochemical Approach to Explore the Cardioprotective Effect of Vasopressin and Milrinone Against Phosphide Toxicity in Rats, Food and Chemical Toxicology (2015)
6. Adverse Effects of Organophosphorus Pesticides on the Liver: A Brief Summary of Four Decades of Research, Arhiv za Higijenu Rada i Toksikologiju (2017)
7. Phosalone-Induced Inflammation and Oxidative Stress in the Colon: Evaluation and Treatment, World Journal of Gastroenterology (2016)
8. Growing Knowledge of Using Embryonic Stem Cells As a Novel Tool in Developmental Risk Assessment of Environmental Toxicants, Life Sciences (2016)
Experts (# of related papers)
View all Related Experts
Mohammad Abdollahi (47)
Maryam Baeeri (29)
Other Related Docs
9. The Association Between Diazinon Exposure and Dyslipidemia Occurrence: A Systematic and Meta-Analysis Study, Environmental Science and Pollution Research (2021)
10. On the Protection by the Combination of Ceo2 Nanoparticles and Sodium Selenite on Human Lymphocytes Against Chlorpyrifos-Induced Apoptosis in Vitro, Cell Journal (2015)
11. A Mechanistic Approach for Modulation of Chlorpyrifos-Induced Toxicity in Human Lymphocytes by Melatonin, Coenzyme Q10, and Vinpocetine, Human and Experimental Toxicology (2016)
12. Cerium and Yttrium Oxide Nanoparticles and Nano-Selenium Produce Protective Effects Against H2o2-Induced Oxidative Stress in Pancreatic Beta Cells by Modulating Mitochondrial Dysfunction, Pharmaceutical Nanotechnology (2020)
13. Assessment of Benzene Induced Oxidative Impairment in Rat Isolated Pancreatic Islets and Effect on Insulin Secretion, Environmental Toxicology and Pharmacology (2015)
14. Effects of Methyl Mercury on the Activity and Gene Expression of Mouse Langerhans Islets and Glucose Metabolism, Food and Chemical Toxicology (2016)
15. Cerium and Yttrium Oxide Nanoparticles Against Lead-Induced Oxidative Stress and Apoptosis in Rat Hippocampus, Biological Trace Element Research (2015)
16. Molecular Evidence on the Protective Effect of Ellagic Acid on Phosalone-Induced Senescence in Rat Embryonic Fibroblast Cells, Food and Chemical Toxicology (2017)
17. Biochemical and Molecular Evidences on the Protection by Magnesium Oxide Nanoparticles of Chlorpyrifos-Induced Apoptosis in Human Lymphocytes, Journal of Research in Medical Sciences (2015)
18. The Chemoprotective Effects of L-Carnitine Against Genotoxicity Induced by Diazinon in Rat Blood Lymphocyte, Toxicology and Industrial Health (2015)
19. On the Mechanisms of Melatonin in Protection of Aluminum Phosphide Cardiotoxicity, Archives of Toxicology (2017)
20. Cellular and Molecular Mechanisms of Pentoxifylline's Beneficial Effects in Experimental Polycystic Ovary, Theriogenology (2015)
21. Multiple Protective Mechanisms of Alpha-Lipoic Acid in Oxidation, Apoptosis and Inflammation Against Hydrogen Peroxide Induced Toxicity in Human Lymphocytes, Molecular and Cellular Biochemistry (2015)
22. Comparative Toxicological Study Between Exposed and Non-Exposed Farmers to Organophosphorus Pesticides, Cell Journal (2016)
23. Effects of Acute Malathion Exposure on Liver Mitochondrial Respiratory Chain Enzymes in Rats, Toxicology International (2015)
24. Biosensors and Their Applications in Detection of Organophosphorus Pesticides in the Environment, Archives of Toxicology (2017)
25. Molecular and Biochemical Evidences for Beneficial Effects of Zinc Oxide Nanoparticles in Modulation of Chlorpyrifos Toxicity in Human Lymphocytes, Iranian Journal of Pharmaceutical Research (2018)
26. Protective Effect of Selenium-Based Medicines on Toxicity of Three Common Organophosphorus Compounds in Human Erythrocytes in Vitro, Cell Journal (2016)
27. Functional Improvement in Rats’ Pancreatic Islets Using Magnesium Oxide Nanoparticles Through Antiapoptotic and Antioxidant Pathways, Biological Trace Element Research (2017)
28. Neuro-Protective Effects of Cerium and Yttrium Oxide Nanoparticles on High Glucose-Induced Oxidative Stress and Apoptosis in Undifferentiated Pc12 Cells, Neurological Research (2015)
29. The Link of Organophosphorus Pesticides With Neurodegenerative and Neurodevelopmental Diseases Based on Evidence and Mechanisms, Toxicology (2018)
30. Effect of Styrene Exposure on Plasma Parameters, Molecular Mechanisms and Gene Expression in Rat Model Islet Cells, Environmental Toxicology and Pharmacology (2017)
31. A Systematic Review on the Role of Environmental Toxicants in Stem Cells Aging, Food and Chemical Toxicology (2015)
32. Multi-Organ Toxicity Attenuation by Cerium Oxide and Yttrium Oxide Nanoparticles: Comparing the Beneficial Effects on Tissues Oxidative Damage Induced by Sub-Acute Exposure to Diazinon, Pharmaceutical Nanotechnology (2020)
33. Molecular Mechanisms of Action of Styrene Toxicity in Blood Plasma and Liver, Environmental Toxicology (2017)
34. Antioxidant Genes, the Insecticide Diazinon, and Toxicity, Toxicology: Oxidative Stress and Dietary Antioxidants (2020)
35. Autophagy, Its Mechanisms and Regulation: Implications in Neurodegenerative Diseases, Ageing Research Reviews (2017)
36. Resveratrol: A Panacea Compound for Diazinon-Induced Renal Toxicity, Toxin Reviews (2023)
37. Molecular and Biochemical Evidence on the Protective Role of Ellagic Acid and Silybin Against Oxidative Stress-Induced Cellular Aging, Molecular and Cellular Biochemistry (2018)
38. Investigation of Β-Sitosterol and Prangol Extracted From Achillea Tenoifolia Along With Whole Root Extract on Isolated Rat Pancreatic Islets, Iranian Journal of Pharmaceutical Research (2018)
39. Recent Updates in Imperative Natural Compounds for Healthy Brain and Nerve Function: A Systematic Review of Implications for Multiple Sclerosis, Current Drug Targets (2017)
40. Hesperidin, a Citrus Bioflavonoid, Ameliorates Genotoxicity-Induced by Diazinon in Human Blood Lymphocytes, Drug Research (2015)
41. Reduction of Chlorpyrifos-Induced Toxicity in Human Lymphocytes by Selected Phosphodiesterase Inhibitors, Pesticide Biochemistry and Physiology (2016)
42. Neuroprotective Effects of Cerium Oxide Nanoparticles on Experimental Stress-Induced Depression in Male Rats, Journal of Chemical Neuroanatomy (2020)
43. Vinpocetine Effect on the Juncture of Diabetes and Aging: An In-Vitro Study, Drug Research (2021)
44. Biomedical Applications of Nanoceria: New Roles for an Old Player, Nanomedicine (2018)
45. A Glance at the Therapeutic Potential of Irisin Against Diseases Involving Inflammation, Oxidative Stress, and Apoptosis: An Introductory Review, Pharmacological Research (2018)
46. The Effect of N-Acetyl Cysteine (Nac) on Aluminum Phosphide Poisoning Inducing Cardiovascular Toxicity: A Case–Control Study, SpringerPlus (2016)
47. On the Benefit of Nanocurcumin on Aluminium Phosphide-Induced Cardiotoxicity in a Rat Model, Nanomedicine Research Journal (2019)
48. Evaluation of Hematological Indices Among Insecticides Factory Workers, Heliyon (2022)
49. Effects of Thymol on Amyloid-Β-Induced Impairments in Hippocampal Synaptic Plasticity in Rats Fed a High-Fat Diet, Brain Research Bulletin (2018)
50. Bisphenol A: What Lies Beneath Its Induced Diabetes and the Epigenetic Modulation?, Life Sciences (2018)