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Combined Physical Training Increases Plasma Brain-Derived Neurotropic Factor Levels, But Not Irisin in People Living With Hiv/Aids



Dos Santos Trombeta JC1 ; Junior RCV2 ; Cavaglieri CR1 ; Bonfante ILP1, 3 ; Prestes J4 ; Tibana RA4 ; Ghayomzadeh M5 ; Souza VC4 ; Seyedalinaghi S5 ; Navalta JW6 ; Voltarelli FA7
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Authors Affiliations
  1. 1. Laboratory of Exercise Physiology, School of Physical Education, University of Campinas, SP, Campinas, Brazil
  2. 2. Faculty of Health Sciences, State University of Mato Grosso (UNEMAT), MT, Caceres, Brazil
  3. 3. Federal Institute of Education, Science and Technology of Sao Paulo, Hortolandia campus, SP, Hortolandia, Brazil
  4. 4. Graduate Program in Physical Education, Faculty of Physical Education, Catholic University of Brasilia (UCB), Brasilia, Brazil
  5. 5. Iranian Research center for HIV/AIDS (IRCHA), Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Kinesiology and Nutrition Sciences, University of Nevada, Las Vegas, United States
  7. 7. Graduate Program in Health Sciences, Faculty of Medicine, Federal University of Mato Grosso (UFMT), MS, Cuiaba, Brazil

Source: International Journal of Exercise Science Published:2021

Abstract

International Journal of Exercise Science 14(3): 1004-1017, 2021. This study evaluated plasma levels of brain-derived neurotropic factor (BDNF), irisin, and lactate in people living with HIV/AIDS who completed a combined physical training program. Nineteen HIV+ participants (age: 39.60 ± 10.96 years; carrier time: 7.75 ± 7.88 years; time of ART: 6.41 ± 5.93 years) performed strength/aerobic training (combined physical training) in the same session for 8 weeks and levels of BDNF, irisin, and lactate were assessed. BDNF (pg/mL) was higher post-CPT (Pre: 1258.73 ± 372.30; Post: 1504.17 ± 322.30; p < 0.001). Irisin (ng/mL) showed no change (Pre: 115.61 ± 72.41; Post: 125.87 ± 81.14; p = 0.973). There was positive correlation between irisin and lactate (mmol/L) pre (r = 0.55, p = 0.04), and lactate values were higher in the group with the highest value of irisin (3.65 ± 0.69 x 2.82 ± 0.59, p = 0.02). Combined physical training results in increased basal BDNF in people living with HIV/AIDS, this finding suggests that increased concentration of BDNF may be associated with decreased chances of developing cognitive disorders or HIV-associated dementia. Further studies involving molecular mechanisms on this subject are necessary. © 2021, Western Kentucky University. All rights reserved.
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