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Network Analysis of Liver Cancer: A System Biology Approach Publisher



Arjmand B1 ; Sherafat SJ2 ; Tavirani MR3 ; Moghadam MH4 ; Abbasi MA5
Authors
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Authors Affiliations
  1. 1. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Traditional Medicine and Materia Medica Research Center, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Firoozabadi Hospital, Clinical Research Development Unit (FHCRDU), School of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran

Source: Gastroenterology and Hepatology from Bed to Bench Published:2023


Abstract

Aim: Determining critical dysregulated proteins in liver cancer was the main aim of this study. Background: Liver cancer is a common health problem characterized by difficulties in early diagnosis and rapid progression. Due to the lack of targeted drugs and the other features of the disease, the survival rate for patients is extremely low. Methods: The related dysregulated proteins for liver cancer were retrieved from the STRING database. The queried proteins were included in a network by Cytoscape software, and the central nodes of the network were enriched via gene ontology. Results: Among 11 introduced central nodes (GAPDH, TP53, EGFR, MYC, INS, ALB, IL6, AKT1, VEGFA, CDH1, and HRAS), HRAS and AKT1 were highlighted as critical dysregulated proteins which can be considered as possible biomarkers. Conclusion: Analysis revealed that AKT1, HRAS and the related biochemical pathways (especially HIF-1 signaling pathway) are the possible diagnostic and therapeutic agents of liver cancer. © 2023 Research Institute for Gastroenterology and Liver Diseases. All rights reserved.