Exploratory and Confirmatory Factor Analysis of the Persian Version of the European Organization for Research and Treatment of Cancer Quality of Life-Breast Cancer Questionnaires With 45 and 42 Items: Eortc Qlq-Br45 and Qlq-Br42; [آنالیز عاملی تأییدی و اکت شافی ن سخههای فار سی ابزارهای 45 و 42 سوالی سنجش کیفیت زندگی در سرطان پستان سازمان پژوهش و درمان Eortc Qlq- Br و 42 Eortc Qlq- Br اروپا: 45] Publisher



Haghighat S¹ ; Omidi Z¹ ; Farajivafa V¹ ; Ansari M¹ ; Bagheri A² ; Sadjadian A¹ ; Moghadam S¹ ; Foudazi H³ ; Zayeri F⁴ Show Affiliations
Source: Iranian Journal of Breast Diseases Published:2025

Abstract

Introduction: The EORTC QLQ-BR45 and QLQ-BR42 questionnaires have been developed to measure the quality of life in breast cancer patients, with 22 and 19 additional items, respectively, compared to the QLQ-BR23 questionnaire. The current project had the objective of evaluating the construct validity of the Persian translation of the QLQ-BR45 and QLQ-BR42 questionnaires. Methods: After confirming the Persian translation of the EORT QLQ-BR45 questionnaire, 480 samples were enrolled in the study for its psychometric evaluation. Confirmatory factor analysis was used to assess the performance of the item and scale of the QLQ-BR45 and QLQ-BR42 questionnaires' total scores and their subscales. Due to the lack of statistical acceptance of the calculated indices, the construct validity of the 23 and 22 questions of QLQ-BR45 was assessed separately to suggest a more appropriate scoring system for these questionnaires. Results: In the confirmatory factor analysis of the EORTC QLQ-BR45 tool, the indices RMSEA, NFI, NNFI, and CFI were 0.099, 0.516, 0.638, and 0.676, respectively. The QLQ-BR42 factor analysis showed that the indices were 0.111, 0.742, 0.6, and 0.646, respectively. The factor analysis results for the QLQBR23 tool showed NFI, NNFI, CFI, and RMSEA values of 0.830, 0.886, 0.909, and 0.061, respectively. In 22 additional items of the QLQ-BR45, these indexes were 0.853, 0.917, 0.913, and 0.07, respectively, all of which indicate acceptable model fit. Conclusion: As per the current study, the 45 items in the EORTC QLQ-BR45 tool are not a good fit in the combined factor model. Instead of integrating the two sections mentioned, it is suggested that the new 22-item tool be used as an instrument to assess the quality of life in breast cancer patients. Copyright © 2025 Haghighat et al.