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Various Interferon (Ifn)-Inducible Transmembrane (Ifitm) Proteins for Covid-19, Is There a Role for the Combination of Mycophenolic Acid and Interferon? Publisher Pubmed



Dowran R1 ; Nabavi SF2, 3 ; Habtemariam S4 ; Banach M5, 6 ; Shahmohamadnejad S7 ; Cismaru CA8, 9 ; Berindanneagoe I8, 11 ; Sahebnasagh A10 ; Nabavi SM2, 3
Authors
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Authors Affiliations
  1. 1. Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
  3. 3. Division of Translational Medicine, Baqiyatallah Hospital, Baqiyatallah University of Medical Sciences, Tehran, Iran
  4. 4. Pharmacognosy Research Laboratories & Herbal Analysis Services UK, University of Greenwich, Chatham-Maritime, Kent, ME4 4TB, United Kingdom
  5. 5. Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Poland
  6. 6. Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland
  7. 7. Department of Clinical Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Research Center for Functional Genomics, Biomedicine and Translational Medicine, The “Iuliu Hatieganu� University of Medicine and Pharmacy, Cluj-Napoca, Romania
  9. 9. Department of Functional Sciences, Immunology and Allergology, The “Iuliu Hatieganu� University of Medicine and Pharmacy, Cluj-Napoca, Romania
  10. 10. Clinical Research Center, Department of Internal Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
  11. 11. Functional Genomics and Experimental Pathology, The Oncology Institute “Prof. Dr. Ion Chiricuta�, Cluj-Napoca, Romania

Source: Biochimie Published:2020


Abstract

Various interferon (IFN)-inducible transmembrane (IFITM) proteins are known to be expressed in human tissues though only IFITM 1–3 are inducible by IFN. Numerous studies have shown that activation of IFITM3 could suppress infection by influenza and coronaviruses such as the Middle East Respiratory Syndrome Coronavirus (MERS-CoV). In view of the potential application of IFITM proteins’ induction to target SARS-CoV-2 infection that causes COVID-19, this article layout insights into the known antiviral mechanisms and therapeutic agents related to IFITM. Blocking viral entry through various mechanisms and the potential application of the FDA approved immunosuppressant agent, mycophenolic acid, as inducer of IFITM3 are among those discussed. © 2020 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM)
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