Comparing the Anomaly Diagnosis Value of Scanning and Triple Screening Test With Amniocentesis in Diagnosing Aneuploidy in the Second Three Months of Pregnancy



Mohammadifard M¹ ; Ghanbarzadeh N² ; Zardast M³ ; Ghafouri M³ ; Mohammadifard M¹
Source: Annals of Tropical Medicine and Public Health Published:2018

Abstract

Background: Early diagnosis of congenital abnormalities in the early and last phases of pregnancy can help prevent the birth of disabled kids who are a burden on the family and society. The present research seeks to study the anomaly diagnosis value of scanning and triple screening test in diagnosing aneuploidy in the second three months of pregnancy. Materials and Method: The present research was conducted on all pregnant women within the second three months of pregnancy resorting to the midwifery clinic of educational hospitals and gynecological centers of faculty members of Birjand Medical Sciences University in 2015 who had at least one criteria needed to enter the research. The data collection tool included a questionnaire which dealt with the information achieved through the anomaly results of sonographic scanning (NB, NT, and NF), Triple Test (Afp, BHCG, Unconjugate striol) and amniocentesis. The data was analyzed using SPSS 15 and the required formula were used to calculate sensitivity, peculiarity, positive and negative predictive value and positive and negative likelihood. Results: Based on the results achieved, the sensitivity, peculiarity and positive and negative predictive value of sonographic scanning anomaly screening compared to amniocentesis was 62.86%, 77%, 28.95%, and 93.3% respectively. As of the sensitivity, peculiarity, positive and negative predictive value of Triple Test compared with amniocentesis, the following values were reported respectively: 97.15%, 8.5%, 13.6%., and 95.24%. Conclusion: As the sensitivity of Triple Test method in diagnosing aneuploidy in the second three months of pregnancy was more than the sensitivity of sonographic scan anomaly method, this method can be designated as the routine nationwide screening method. © 2018 Medknow Publications. All rights reserved.