Preparation, Characterization and Stability Investigation of Chitosan Nanoparticles Loaded With the Echis Carinatus Snake Venom As a Novel Delivery System

Preparation, Characterization and Stability Investigation of Chitosan Nanoparticles Loaded With the Echis Carinatus Snake Venom As a Novel Delivery System

Mohammadpour Dounighi N¹ ; Mehrabi M² ; Avadi MR³ ; Zolfagharian H¹ ; Rezayat M⁴

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1. Department of Venomous animals and Human Sera, Razi Vaccine and oSera Research Institute, Karaj, Iran
2. Department of Nanotechnology, Faculty of Advanced Sciences and Technology in Medicine, Tehran University of Medical Science, Tehran, Iran
3. Research and Development Department, Hakim pharmaceutical company, Tehran, Iran
4. Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Archives of Razi Institute Published:2015

Abstract

The chitosan nanoparticles used widely as a drug delivery systems recently. In the present study the Echis carinataus snake venom loaded chitosan nanoparticles were prepared based on ionic gelation of tripolyphosphate and chitosan. The nanoparticles physicochemical characteristics, stability and biological activity of encapsulated venom were studied. The particles were spherical in shape and the tripolyphosphoric groups of TPP were linked to the ammonium groups of chitosan. Optimum particle size of chitosan and venom loaded nanoparticles were 89 and 116 nm, respectively. Optimum loading capacity and loading efficiency obtained by 500 μg/ml concentration of venom. The biological activity of venom remained intact during nanoparticle formation and showed no considerable reduction in stability analysis. Our results suggested that chitosan nanoparticles, which prepared in this work possibly, could be used as an alternative for traditional adjuvants. © 2015.

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Style	Citing Format
MLA	Mohammadpour Dounighi N, et al.. "Preparation, Characterization and Stability Investigation of Chitosan Nanoparticles Loaded With the Echis Carinatus Snake Venom As a Novel Delivery System." Archives of Razi Institute, vol. 70, no. 4, 2015, pp. 269-277.
APA	Mohammadpour Dounighi N, Mehrabi M, Avadi MR, Zolfagharian H, Rezayat M (2015). Preparation, Characterization and Stability Investigation of Chitosan Nanoparticles Loaded With the Echis Carinatus Snake Venom As a Novel Delivery System. Archives of Razi Institute, 70(4), 269-277.
Chicago	Mohammadpour Dounighi N, Mehrabi M, Avadi MR, Zolfagharian H, Rezayat M. "Preparation, Characterization and Stability Investigation of Chitosan Nanoparticles Loaded With the Echis Carinatus Snake Venom As a Novel Delivery System." Archives of Razi Institute 70, no. 4 (2015): 269-277.
Harvard	Mohammadpour Dounighi N et al. (2015) 'Preparation, Characterization and Stability Investigation of Chitosan Nanoparticles Loaded With the Echis Carinatus Snake Venom As a Novel Delivery System', Archives of Razi Institute, 70(4), pp. 269-277.
Vancouver	Mohammadpour Dounighi N, Mehrabi M, Avadi MR, Zolfagharian H, Rezayat M. Preparation, Characterization and Stability Investigation of Chitosan Nanoparticles Loaded With the Echis Carinatus Snake Venom As a Novel Delivery System. Archives of Razi Institute. 2015;70(4):269-277.
BibTex	@article{ author = {Mohammadpour Dounighi N and Mehrabi M and Avadi MR and Zolfagharian H and Rezayat M}, title = {Preparation, Characterization and Stability Investigation of Chitosan Nanoparticles Loaded With the Echis Carinatus Snake Venom As a Novel Delivery System}, journal = {Archives of Razi Institute}, volume = {70}, number = {4}, pages = {269-277}, year = {2015} }
RIS	TY - JOUR AU - Mohammadpour Dounighi N AU - Mehrabi M AU - Avadi MR AU - Zolfagharian H AU - Rezayat M TI - Preparation, Characterization and Stability Investigation of Chitosan Nanoparticles Loaded With the Echis Carinatus Snake Venom As a Novel Delivery System JO - Archives of Razi Institute VL - 70 IS - 4 SP - 269 EP - 277 PY - 2015 ER -

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