A Review on Progression of Epidermal Growth Factor Receptor (Egfr) Inhibitors As an Efficient Approach in Cancer Targeted Therapy

A Review on Progression of Epidermal Growth Factor Receptor (Egfr) Inhibitors As an Efficient Approach in Cancer Targeted Therapy Publisher Pubmed

Ayati A¹ ; Moghimi S¹ ; Salarinejad S² ; Safavi M³ ; Pouramiri B¹ ; Foroumadi A^{1, 2}

Show Affiliations

1. Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran
2. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3. Department of Biotechnology, Iranian Research Organization for Science and Technology, P.O. Box 3353-5111, Tehran, Iran

Source: Bioorganic Chemistry Published:2020

Abstract

The identification of molecular agents inhibiting specific functions in cancer cells progression is considered as one of the most successful plans in cancer treatment. The epidermal growth factor receptor (EGFR) over-activation is observed in a vast number of cancers, so, targeting EGFR and its downstream signaling cascades are regarded as a rational and valuable approach in cancer therapy. Several synthetic EGFR tyrosine kinase inhibitors (TKIs) have been evaluated in recent years, mostly exhibited clinical efficacy in relevant models and categorized into first, second, third and fourth-generation. However, studies are still ongoing to find more efficient EGFR inhibitors in light of the resistance to the current inhibitors. In this review, the importance of targeting EGFR signaling pathway in cancer therapy and related epigenetic mutations are highlighted. The recent advances on the discovery and development of different EGFR inhibitors and the use of various therapeutic strategies such as multi-targeting agents and combination therapies have also been reviewed. © 2020 Elsevier Inc.

Style	Citing Format
MLA	Ayati A, et al.. "A Review on Progression of Epidermal Growth Factor Receptor (Egfr) Inhibitors As an Efficient Approach in Cancer Targeted Therapy." Bioorganic Chemistry, vol. 99, no. , 2020, pp. -.
APA	Ayati A, Moghimi S, Salarinejad S, Safavi M, Pouramiri B, Foroumadi A (2020). A Review on Progression of Epidermal Growth Factor Receptor (Egfr) Inhibitors As an Efficient Approach in Cancer Targeted Therapy. Bioorganic Chemistry, 99(), -.
Chicago	Ayati A, Moghimi S, Salarinejad S, Safavi M, Pouramiri B, Foroumadi A. "A Review on Progression of Epidermal Growth Factor Receptor (Egfr) Inhibitors As an Efficient Approach in Cancer Targeted Therapy." Bioorganic Chemistry 99, no. (2020): -.
Harvard	Ayati A et al. (2020) 'A Review on Progression of Epidermal Growth Factor Receptor (Egfr) Inhibitors As an Efficient Approach in Cancer Targeted Therapy', Bioorganic Chemistry, 99(), pp. -.
Vancouver	Ayati A, Moghimi S, Salarinejad S, Safavi M, Pouramiri B, Foroumadi A. A Review on Progression of Epidermal Growth Factor Receptor (Egfr) Inhibitors As an Efficient Approach in Cancer Targeted Therapy. Bioorganic Chemistry. 2020;99():-.
BibTex	@article{ author = {Ayati A and Moghimi S and Salarinejad S and Safavi M and Pouramiri B and Foroumadi A}, title = {A Review on Progression of Epidermal Growth Factor Receptor (Egfr) Inhibitors As an Efficient Approach in Cancer Targeted Therapy}, journal = {Bioorganic Chemistry}, volume = {99}, number = {}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Ayati A AU - Moghimi S AU - Salarinejad S AU - Safavi M AU - Pouramiri B AU - Foroumadi A TI - A Review on Progression of Epidermal Growth Factor Receptor (Egfr) Inhibitors As an Efficient Approach in Cancer Targeted Therapy JO - Bioorganic Chemistry VL - 99 IS - SP - EP - PY - 2020 ER -

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Abstract