Protective Effects of Tropisetron on Cerulein-Induced Acute Pancreatitis in Mice Publisher Pubmed



Rahimian R^{1, 2} ; Zirak MR³ ; Seyedabadi M⁴ ; Keshavarz M^{4, 5} ; Rashidian A² ; Kazmi S⁶ ; Jafarian AH⁷ ; Karimi G⁸ ; Mousavizadeh K⁹
Source: Biomedicine and Pharmacotherapy Published:2017

Abstract

Acute pancreatitis (AP) causes morbidity and mortality. The aim of the present study was to investigate the protective effect of tropisetron against AP induced by cerulein. Cerulein (50 μg/kg, 5 doses) was used to induce AP in mice. Six hours after final cerulein injection, animals were decapitated. Hepatic/pancreatic enzymes in the serum, pancreatic content of malondialdehyde (MDA), pro-inflammatory cytokines and myeloperoxidase (MPO) activity were measured. Tropisetron significantly attenuated pancreatic injury markers and decreased the amount of elevated serum amylase, lipase, alanine aminotransferase (ALT), aspartate aminotransferase (AST), MPO activities and pro-inflammatory cytokines levels caused by AP in mice. Tropisetron didn't affect the pancreatic levels of MDA. Our results suggest that tropisetron could attenuate cerulein-induced AP by combating inflammatory signaling. Further clinical studies are needed to confirm its efficacy in patients with AP. © 2017 Elsevier Masson SAS