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A Fast-Degradable Nano-Dressing With Potent Antibacterial Effect Publisher



Zarenezhad E1 ; Abdollahi A2 ; Esmaeili F3 ; Satvati S4 ; Osanloo M5
Authors
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Authors Affiliations
  1. 1. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran
  2. 2. Department of Microbiology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran
  3. 3. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Medical Biotechnology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran
  5. 5. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran

Source: BioNanoScience Published:2020


Abstract

In this study, clove essential oil was used as a green antibacterial agent. Its nanoemulsion dosage form with particle size 217.7 ± 11.45 nm and PDI 0.66 ± 0.09 was first prepared. By adding carbomer 940, nanoemulsion was then transformed into the nanogel (NGel) to improve the essential oil’s activity and stability. Electrospun nanofibers of polyvinyl alcohol (PVANFs) with a mean diameter of 216 ± 14 nm were then prepared. The required characterizations such as ATR-FTIR spectroscopy, SEM image, and water contact angle were carried out. To easy usage topically, the NGel was impregnated on the PVANFs mat (NGelNFs). Interestingly, the prepared fast-degradable NGelNFs could inhibit (100%) the growth of four important pathogens, including Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumonia. Besides, the dressing was degraded after minutes of usage. The prepared GelNFs could be used as a capable and fast-degradable antibacterial substrate. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
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