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Identification of Common Hub Genes and Key Molecular Pathways Between Multiple Sclerosis and Urological Disorders Publisher



S Aliyari SHAHRAM ; Z Salehi ZAHRA ; K Kavousi KAVEH ; Ha Azodian Ghajar Helia AZODIAN ; P Nikoofar PARSA ; R Omid REZA ; Pd Farashah Parmida DEHGHANPOOR ; H Homayoun HASSAN ; V Abedi Yarandi VAHID
Authors

Source: Translational Research in Urology Published:2024


Abstract

Introduction The immune system plays a vital role in affording protection for the body against a wide variety of diseases and infections. On occasion, the system malfunctions and attacks intact cells, tissues, and organs influencing any part of the body, tapering off bodily function, and leading to life-threatening. multiple sclerosis (MS) is characterized by inflammatory demyelination with a diverse range of urologic indications. Methods To extract the overlapped genes and single-nucleotide polymorphisms (SNPs; until November 2022) between MS and several urological disorders, we searched the DisGeNET database. Furthermore, to identify significant Gene Ontology (GO) terms and the Kyoto Encyclopedia of Genes and Genome (KEGG) pathway, the Enrichr assessment was used. Additionally, in the case of overlapped genes, the maximum level of linkage hub genes was investigated by the protein-protein interaction (PPI) network construction via cytoHubba. Results 1362 common genes between MS and urological disease were recognized, of which 154 genes have SNPs linked with MS susceptibility. Three DisGeNET-indexed MS-associated SNPs, including rs653178, rs10936599, and rs4976646 were shared between MS and urological disorders. TNF, AKT1, IL1B, IL6, VEGFA, INS, C-C CCL5, TP53), RELA proto-oncogene, STAT3, and EGFR were detected as hub genes overrepresented in the identified pathways. Conclusions Of 1362 common genes, 11 key genes, and 3 SNPs were shared between MS and urology-related diseases. These identified features might serve as potential therapeutic targets in both disorders, with a probable role in the management of urological complications in MS patients. © 2024 Elsevier B.V., All rights reserved.
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