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Genetic Variants of Cytochrome B-245, Alpha Polypeptide Gene and Premature Acute Myocardial Infarction Risk in an Iranian Population Publisher



Amin F1 ; Jahani MM2 ; Ghaedi H3 ; Alipoor B4 ; Fatemi A5 ; Tajik M3 ; Sharifi Z6 ; Golmohammadi T4 ; Askari M7 ; Azarnejad A8 ; Alipoor S9 ; Valipour A10 ; Mousavizadeh K11
Authors
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Authors Affiliations
  1. 1. Department of Physiology, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
  2. 2. Faculty of Veterinary Science, Shahrekord Islamic Azad University, Shahrekord, Iran
  3. 3. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Hematology, School of Allied Medical Sciences, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
  7. 7. Department of Medical Biotechnology, Pasteur Institute of Iran, Tehran, Iran
  8. 8. Department of Medical Genetics, Tehran University of Medical Sciences, Tehran, Iran
  9. 9. Department of Nutrition, School of Health, Yasouj University of Medical Sciences, Yasouj, Iran
  10. 10. Health Center Baghmalek, School of Health, Ahvaz University of Medical Sciences, Ahvaz, Iran
  11. 11. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran

Source: Journal of Medical Biochemistry Published:2015


Abstract

Background: Oxidative stress induced by superoxide anion plays critical roles in the pathogenesis of coronary artery disease (CAD) and hence acute myocardial infarction (AMI). The major source of superoxide production in vascular smooth muscle and endothelial cells is the NADPH oxidase complex. An essential component of this complex is p22phox, that is encoded by the cytochrome b-245, alpha polypeptide (CYBA) gene. The aim of this study was to investigate the association of CYBA variants (rs1049255 and rs4673) and premature acute myocardial infarction risk in an Iranian population. Methods: The study population consisted of 158 patients under the age of 50 years, with a diagnosis of premature AMI, and 168 age-matched controls with normal coronary angiograms. Genotyping of the polymorphisms was performed by the polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). Results: There was no association between the genotypes and allele frequencies of rs4673 polymorphism and premature acute myocardial infarction (P>0.05). A significant statistical association was observed between the genotypes distribution of rs1049255 polymorphism and AMI risk (P=0.037). Furthermore, the distribution of AA+AG/GG genotypes was found to be statistically significant between the two groups (P=0.011). Conclusions: Our findings indicated that rs1049255 but not rs4673 polymorphism is associated with premature AMI.
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