Toxicity of Hydrogen Sulfide on Rat Brain Neurons

Toxicity of Hydrogen Sulfide on Rat Brain Neurons Publisher Pubmed

Seydi E^{1, 2} ; Irandoost Z³ ; Khansari MG⁴ ; Naserzadeh P³ ; Tanbakosazan F³ ; Pourahmad J³

Show Affiliations

1. Department of Occupational Health and Safety Engineering, School of Health, Alborz University of Medical Sciences, Karaj, Iran
2. Research Center for Health, Safety and Environment, Alborz University of Medical Sciences, Karaj, Iran
3. Department of Toxicology and Pharmacology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Drug Research Published:2022

Abstract

Hydrogen sulfide (H2S) is a toxic compound known as a member of the gasotransmitter family. H2S has the ability to inhibit the cytochrome c oxidase enzyme in the mitochondrial respiratory chain. Mitochondria play an important role in energy production and the brain needs energy for normal function. Mitochondrial dysfunction is associated with neurodegenerative diseases. This study investigated the mechanisms of cytotoxicity induced by H2S in brain neurons. thioacetamide has been used to produce H2S in water solutions. The results of the study showed that thioacetamide at concentrations of 116, 232 and 464 µg/ml was able to increase the level of reactive oxygen species (ROS), collapse in mitochondrial membrane potential (MMP), damage to the lysosomal membrane, increase in the level of oxidized glutathione (GSSG) and decrease in the level of reduced glutathione (GSH) in brain neurons. The results of the study suggested that H2S causes damage to mitochondria and lysosomes in brain neurons that could be associated with neurodegenerative diseases. © 2022. Thieme. All rights reserved. Georg Thieme Verlag KG, Rudigerstraße 14, 70469 Stuttgart, Germany

Style	Citing Format
MLA	Seydi E, et al.. "Toxicity of Hydrogen Sulfide on Rat Brain Neurons." Drug Research, vol. 72, no. 4, 2022, pp. 197-202.
APA	Seydi E, Irandoost Z, Khansari MG, Naserzadeh P, Tanbakosazan F, Pourahmad J (2022). Toxicity of Hydrogen Sulfide on Rat Brain Neurons. Drug Research, 72(4), 197-202.
Chicago	Seydi E, Irandoost Z, Khansari MG, Naserzadeh P, Tanbakosazan F, Pourahmad J. "Toxicity of Hydrogen Sulfide on Rat Brain Neurons." Drug Research 72, no. 4 (2022): 197-202.
Harvard	Seydi E et al. (2022) 'Toxicity of Hydrogen Sulfide on Rat Brain Neurons', Drug Research, 72(4), pp. 197-202.
Vancouver	Seydi E, Irandoost Z, Khansari MG, Naserzadeh P, Tanbakosazan F, Pourahmad J. Toxicity of Hydrogen Sulfide on Rat Brain Neurons. Drug Research. 2022;72(4):197-202.
BibTex	@article{ author = {Seydi E and Irandoost Z and Khansari MG and Naserzadeh P and Tanbakosazan F and Pourahmad J}, title = {Toxicity of Hydrogen Sulfide on Rat Brain Neurons}, journal = {Drug Research}, volume = {72}, number = {4}, pages = {197-202}, year = {2022} }
RIS	TY - JOUR AU - Seydi E AU - Irandoost Z AU - Khansari MG AU - Naserzadeh P AU - Tanbakosazan F AU - Pourahmad J TI - Toxicity of Hydrogen Sulfide on Rat Brain Neurons JO - Drug Research VL - 72 IS - 4 SP - 197 EP - 202 PY - 2022 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract