Improved Voriconazole Topical Delivery by Nanoparticles (Minireview)

Improved Voriconazole Topical Delivery by Nanoparticles (Minireview) Publisher

Nassirikashani M¹ ; Namdar R^{2, 3} ; Nafisi S^{2, 3} ; Maibach HI³

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1. Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Chemistry, Central Tehran Branch, Tehran, IAU, Iran
3. Department of Dermatology, University of California, San Francisco, CA, United States

Source: Pharmaceutical Chemistry Journal Published:2016

Abstract

Voriconazole is a triazole antifungal drug used to treat invasive fungal infections including candidiasis, aspergillosis, and certain emerging fungal infections. Voriconazole demonstrates low water solubility. Therefore, drug solubilization is necessary for effective topical delivery. Nano-strategy may overcome its poor aqueous solubility as well as controlled drug release at action site, reduction of total dose, avoidance of systemic absorption and dosage form retention on skin. In topical antifungal administration, drug should pass outermost layer of skin; stratum corneum to reach lower layers, particularly into follicular epithelium. Nano-formulations including colloidal systems, vesicular carriers, and nanoparticles may play a major role for enhancing antifungals permeation profile. Present review surveys key experiments with voriconazole nano-based formulations used in superficial fungal infections treatment. © 2016, Springer Science+Business Media New York.

Style	Citing Format
MLA	Nassirikashani M, et al.. "Improved Voriconazole Topical Delivery by Nanoparticles (Minireview)." Pharmaceutical Chemistry Journal, vol. 50, no. 2, 2016, pp. 76-79.
APA	Nassirikashani M, Namdar R, Nafisi S, Maibach HI (2016). Improved Voriconazole Topical Delivery by Nanoparticles (Minireview). Pharmaceutical Chemistry Journal, 50(2), 76-79.
Chicago	Nassirikashani M, Namdar R, Nafisi S, Maibach HI. "Improved Voriconazole Topical Delivery by Nanoparticles (Minireview)." Pharmaceutical Chemistry Journal 50, no. 2 (2016): 76-79.
Harvard	Nassirikashani M et al. (2016) 'Improved Voriconazole Topical Delivery by Nanoparticles (Minireview)', Pharmaceutical Chemistry Journal, 50(2), pp. 76-79.
Vancouver	Nassirikashani M, Namdar R, Nafisi S, Maibach HI. Improved Voriconazole Topical Delivery by Nanoparticles (Minireview). Pharmaceutical Chemistry Journal. 2016;50(2):76-79.
BibTex	@article{ author = {Nassirikashani M and Namdar R and Nafisi S and Maibach HI}, title = {Improved Voriconazole Topical Delivery by Nanoparticles (Minireview)}, journal = {Pharmaceutical Chemistry Journal}, volume = {50}, number = {2}, pages = {76-79}, year = {2016} }
RIS	TY - JOUR AU - Nassirikashani M AU - Namdar R AU - Nafisi S AU - Maibach HI TI - Improved Voriconazole Topical Delivery by Nanoparticles (Minireview) JO - Pharmaceutical Chemistry Journal VL - 50 IS - 2 SP - 76 EP - 79 PY - 2016 ER -

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