Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Effect of Semelil, an Herbal Selenium-Based Medicine, on New Bone Formation in Calvarium of Rabbits Publisher Pubmed



Rasoulighahroudi AA1 ; Rokn A1 ; Abdollahi M2 ; Mashhadiabbas F3 ; Yaghobee S1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Periodontics, Dental Implant Research Center, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Toxicology and Disease Group, Pharmaceutical Sciences Research Center, Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Oral Maxillofacial Pathology Department, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: BioMed Research International Published:2018


Abstract

Background. This study aims to analyze the effect of Semelil, an herbal selenium-based medicine, on osteogenesis in rabbit calvarium defects. Methods. Four identical bony defects (8 mm) were created in the calvarium of 16 New Zealand male rabbits and filled randomly with xenogenic bone substitute material (Bio-Oss®) and semelil herbal drug (ANGIPARS™). One site was filled with Bio-Oss (B); the second site was treated with ANGIPARS (A); the third site was treated with ANGIPARS + Bio-Oss (AB); and the fourth site was left as untreated control (C) and defects were left unfilled. Rabbits were randomly divided into two groups (n=8) and sacrificed at four and eight weeks. Percentage of new bone formation, type of the newly formed bone, percentage of the remaining xenograft biomaterial, and foreign body reaction (FBR) were evaluated via histological and histomorphometric analyses. Results. The percentage of new bone formation was significantly different among four groups. The highest effect was observed in AB, followed by A, B, and C groups, respectively. The difference in the mean percentage of new bone formation between four and eight weeks was significant for all four groups (P<0.001). Regarding bone formation, the interaction effect of A and B was significant at four (P<0.001) and eight weeks (P=0.002). ANGIPARS alone and in presence of Bio-Oss enhanced new bone formation at both four and eight weeks (P<0.001). The mean amount of new bone formation was significantly different at four and eight weeks in groups C (P=0.008), A (P<0.001), B (P<0.001), and AB (P=0.003). FBR was not observed in any group. Conclusion. Semelil may be useful as an adjunct to conventional osteoconductive materials in order to enhance osteogenesis. © 2018 Amir Alireza Rasouli-Ghahroudi et al.
Related Docs
1. Semelil As Adjunctive Therapy in Chronic Periodontitis: A Preliminary Randomized Controlled Clinical Study, Iranian Journal of Pharmaceutical Research (2021)
2. Antioxidant and Protective Effects of Angipars™, a New Herbal Drug, on Hydrogen Peroxide-Induced Oxidative Stress in Hepg2 and A549 Cell Lines, Jundishapur Journal of Natural Pharmaceutical Products (2016)
3. Protective Effect of Selenium-Based Medicines on Toxicity of Three Common Organophosphorus Compounds in Human Erythrocytes in Vitro, Cell Journal (2016)
4. In Vitro Protection of Human Lymphocytes From Toxic Effects of Chlorpyrifos by Selenium-Enriched Medicines, Iranian Journal of Basic Medical Sciences (2015)
5. Dual Targeting of Tnf- Α and Free Radical Toxic Stress As a Promising Strategy to Manage Experimental Polycystic Ovary, Pharmaceutical Biology (2016)
Experts (# of related papers)
View all Related Experts
Mohammad Abdollahi (5)
Maryam Baeeri (3)