One-Pot Four-Component Synthesis of Thieno[2,3-D]Pyrimidin-4-Amines Via Sequential Gewald/Cyclocondensation Reactions

One-Pot Four-Component Synthesis of Thieno[2,3-D]Pyrimidin-4-Amines Via Sequential Gewald/Cyclocondensation Reactions Publisher

Adib M¹ ; Janatian Ghazvini H¹ ; Soheilizad M¹ ; Saeedi S¹ ; Tajbakhsh M² ; Amanlou M³

Show Affiliations

1. School of Chemistry, College of Science, University of Tehran, P. O. Box 14155-6455, Tehran, Iran
2. Department of Organic Chemistry, Faculty of Chemistry, Mazandaran University, Babolsar, Iran
3. Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Helvetica Chimica Acta Published:2015

Abstract

A one-pot four-component synthesis of thieno[2,3-d]pyrimidin-4-amines via sequential Gewald/cyclocondensation reactions is described. 2-Aminothiophene-3-carbonitriles obtained from the Gewald reaction between cyclic ketones, malononitrile, and sulfur underwent a condensation-cyclization reaction with benzonitriles under solvent-free conditions to afford the title compounds in excellent yields. Copyright © 2015 Verlag Helvetica Chimica Acta AG, Zurich.

Style	Citing Format
MLA	Adib M, et al.. "One-Pot Four-Component Synthesis of Thieno[2,3-D]Pyrimidin-4-Amines Via Sequential Gewald/Cyclocondensation Reactions." Helvetica Chimica Acta, vol. 98, no. 8, 2015, pp. 1079-1086.
APA	Adib M, Janatian Ghazvini H, Soheilizad M, Saeedi S, Tajbakhsh M, Amanlou M (2015). One-Pot Four-Component Synthesis of Thieno[2,3-D]Pyrimidin-4-Amines Via Sequential Gewald/Cyclocondensation Reactions. Helvetica Chimica Acta, 98(8), 1079-1086.
Chicago	Adib M, Janatian Ghazvini H, Soheilizad M, Saeedi S, Tajbakhsh M, Amanlou M. "One-Pot Four-Component Synthesis of Thieno[2,3-D]Pyrimidin-4-Amines Via Sequential Gewald/Cyclocondensation Reactions." Helvetica Chimica Acta 98, no. 8 (2015): 1079-1086.
Harvard	Adib M et al. (2015) 'One-Pot Four-Component Synthesis of Thieno[2,3-D]Pyrimidin-4-Amines Via Sequential Gewald/Cyclocondensation Reactions', Helvetica Chimica Acta, 98(8), pp. 1079-1086.
Vancouver	Adib M, Janatian Ghazvini H, Soheilizad M, Saeedi S, Tajbakhsh M, Amanlou M. One-Pot Four-Component Synthesis of Thieno[2,3-D]Pyrimidin-4-Amines Via Sequential Gewald/Cyclocondensation Reactions. Helvetica Chimica Acta. 2015;98(8):1079-1086.
BibTex	@article{ author = {Adib M and Janatian Ghazvini H and Soheilizad M and Saeedi S and Tajbakhsh M and Amanlou M}, title = {One-Pot Four-Component Synthesis of Thieno[2,3-D]Pyrimidin-4-Amines Via Sequential Gewald/Cyclocondensation Reactions}, journal = {Helvetica Chimica Acta}, volume = {98}, number = {8}, pages = {1079-1086}, year = {2015} }
RIS	TY - JOUR AU - Adib M AU - Janatian Ghazvini H AU - Soheilizad M AU - Saeedi S AU - Tajbakhsh M AU - Amanlou M TI - One-Pot Four-Component Synthesis of Thieno[2,3-D]Pyrimidin-4-Amines Via Sequential Gewald/Cyclocondensation Reactions JO - Helvetica Chimica Acta VL - 98 IS - 8 SP - 1079 EP - 1086 PY - 2015 ER -

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