Associated Factors of Drug-Drug Interactions of Highly Active Antiretroviral Therapy: Report From a Referral Center

Associated Factors of Drug-Drug Interactions of Highly Active Antiretroviral Therapy: Report From a Referral Center Publisher Pubmed

Farhoudi M¹ ; Khalili H² ; Karimzadeh I³ ; Abbasian L⁴

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1. International Campus, Tehran University of Medical Sciences, Tehran, Iran
2. Tehran University of Medical Sciences, Department of Clinical Pharmacy, Faculty of Pharmacy, Enghelab Ave, Tehran, 1417614411, Iran
3. Shiraz University of Medical Sciences, Department of Clinical Pharmacy, Faculty of Pharmacy, Shiraz, Iran
4. Tehran University of Medical Sciences, Iranian Research Center for HIV/AIDS, Tehran, Iran

Source: Expert Opinion on Drug Metabolism and Toxicology Published:2015

Abstract

Objective: To assess different aspects of potential drug-drug interactions (DDIs) including incidence, severity, level of evidence and probable associated factors in Iranian HIV-infected individuals receiving antiretroviral therapy.Methods: All adult HIV-infected patients under highly active antiretroviral therapy regimen attending a referral HIV clinic during 1 year were screened retrospectively for potential moderate or severe DDIs by the Lexi-Interact On-Desktop software.Results: Near seventy percent (69.89%) of detected DDIs in our population were major. The three most common detected potential DDIs were efavirenz + methadone (11 cases), lopinavir-ritonavir + sulfamethoxazole-trimethoprim, (10 cases) and lamivudine + ribavirin (7 cases). Lopinavir-ritonavir (27.96%) and citalopram (23.66%) were the most common offending antiretroviral and non-antiretroviral agents, respectively.Conclusion: Performing multicenter and prospective studies is warranted to assess the real clinical as well as economic impacts of DDIs on HIV-infected patients receiving antiretroviral agents in our population and also to develop efficient preventive strategies. © 2015 Informa UK, Ltd.

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Style	Citing Format
MLA	Farhoudi M, et al.. "Associated Factors of Drug-Drug Interactions of Highly Active Antiretroviral Therapy: Report From a Referral Center." Expert Opinion on Drug Metabolism and Toxicology, vol. 11, no. 4, 2015, pp. 471-479.
APA	Farhoudi M, Khalili H, Karimzadeh I, Abbasian L (2015). Associated Factors of Drug-Drug Interactions of Highly Active Antiretroviral Therapy: Report From a Referral Center. Expert Opinion on Drug Metabolism and Toxicology, 11(4), 471-479.
Chicago	Farhoudi M, Khalili H, Karimzadeh I, Abbasian L. "Associated Factors of Drug-Drug Interactions of Highly Active Antiretroviral Therapy: Report From a Referral Center." Expert Opinion on Drug Metabolism and Toxicology 11, no. 4 (2015): 471-479.
Harvard	Farhoudi M et al. (2015) 'Associated Factors of Drug-Drug Interactions of Highly Active Antiretroviral Therapy: Report From a Referral Center', Expert Opinion on Drug Metabolism and Toxicology, 11(4), pp. 471-479.
Vancouver	Farhoudi M, Khalili H, Karimzadeh I, Abbasian L. Associated Factors of Drug-Drug Interactions of Highly Active Antiretroviral Therapy: Report From a Referral Center. Expert Opinion on Drug Metabolism and Toxicology. 2015;11(4):471-479.
BibTex	@article{ author = {Farhoudi M and Khalili H and Karimzadeh I and Abbasian L}, title = {Associated Factors of Drug-Drug Interactions of Highly Active Antiretroviral Therapy: Report From a Referral Center}, journal = {Expert Opinion on Drug Metabolism and Toxicology}, volume = {11}, number = {4}, pages = {471-479}, year = {2015} }
RIS	TY - JOUR AU - Farhoudi M AU - Khalili H AU - Karimzadeh I AU - Abbasian L TI - Associated Factors of Drug-Drug Interactions of Highly Active Antiretroviral Therapy: Report From a Referral Center JO - Expert Opinion on Drug Metabolism and Toxicology VL - 11 IS - 4 SP - 471 EP - 479 PY - 2015 ER -

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