Quantum Dot Enhanced Photonic Biosensors for Single Cell Analysis From Synthesis to Clinical Application Publisher

Summary: Can quantum dot biosensors change clinical diagnostics? Research suggests indium phosphide and carbon QDs enhance detection sensitivity. Challenges remain in manufacturing and stability. #Biosensors #QuantumDots

Hooshiar MH ; Hooshiar JH ; Hooshiar SH
Source: Discover Nano Published:2026

Abstract

The quantum dot (QD)-enhanced optical biosensors are very sensitive tools for analyzing single cells. Heavy metal-free alternatives, such as indium phosphide and carbon-based QDs, address safety concerns while achieving high quantum efficiency. Photonic enhancement techniques provide 240-fold signal amplification and quality factors of up to 7000, allowing femtomolar detection limits. However, clinical translation encounters manufacturing scalability and stability problems in complex biological matrices. This review discusses synthetic techniques, surface functionalization, and clinical implementation, highlighting important challenges and potential for improving QD-based biosensors. © The Author(s) 2026.