Molecular and Phenotypic Characteristics of Staphylococcus Hominis Isolates From Pediatric Infections



Saffari F¹ ; Nikmanesh B² Show Affiliations
Source: Journal of Kerman University of Medical Sciences Published:2020

Abstract

Background: Staphylococcus hominis has been recently emerged as an opportunistic hospitalassociated pathogen. The aim of this study was to characterize the antimicrobial susceptibility pattern, biofilm formation, and staphylococcal cassette chromosome mec (SCCmec) types among clinical isolates of S. hominis obtained from pediatric infections. Methods: Totally, twenty-two clinically significant S. hominis isolates, mostly from blood samples, were examined for antibiotic resistance, SCCmec typing, and biofilm formation. Results: Multiresistance was observed in 86 % of isolates. Among mecA positive isolates (77%), SCCmec type I (28%), III (22%), IV (22%), and non-typeable ones (28%) were detected. More than half of the isolates (54.5%) did not produce biofilm. No significant associationwas found between biofilm formation and the presence of ica operon. Conclusion: As S. hominis isolates were not strong biofilm producers, biofilm formation cannot be considered as much as important multidrug resistance.in the pathogenesis of isolates. © 2020, Kerman University of Medical Sciences. All rights reserved.