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Risk Assessment for Mortality in Patients With St-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: A Retrospective Cohort Study Publisher



Oraii A1 ; Shafeghat M2, 3 ; Ashraf H4, 5 ; Soleimani A6 ; Kazemian S4 ; Sadatnaseri A6 ; Saadat N6 ; Danandeh K1 ; Akrami A7 ; Balali P1 ; Fatahi M1 ; Karbalai Saleh S6
Authors
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Authors Affiliations
  1. 1. Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Feinberg School of Medicine, Northwestern University, Chicago, IL, United States
  4. 4. Cardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Research Development Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Cardiology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, IL, United States

Source: Health Science Reports Published:2024


Abstract

Background and Aims: Primary percutaneous coronary intervention (PCI) is the treatment of choice in ST-elevation myocardial infarction (STEMI) patients. This study aims to evaluate predictors of in-hospital and long-term mortality among patients with STEMI undergoing primary PCI. Methods: In this registry-based study, we retrospectively analyzed patients with STEMI undergoing primary PCI enrolled in the primary angioplasty registry of Sina Hospital. Independent predictors of in-hospital and long-term mortality were determined using multivariate logistic regression and Cox regression analyses, respectively. Results: A total of 1123 consecutive patients with STEMI were entered into the study. The mean age was 59.37 ± 12.15 years old, and women constituted 17.1% of the study population. The in-hospital mortality rate was 5.0%. Multivariate analyses revealed that older age (odds ratio [OR]: 1.06, 95% confidence interval [CI]: 1.02–1.10), lower ejection fraction (OR: 0.97, 95% CI: 0.92–0.99), lower mean arterial pressure (OR: 0.95, 95% CI: 0.93–0.98), and higher white blood cells (OR: 1.17, 95% CI: 1.06–1.29) as independent risk predictors for in-hospital mortality. Also, 875 patients were followed for a median time of 21.8 months. Multivariate Cox regression demonstrated older age (hazard ratio [HR] = 1.04, 95% CI: 1.02–1.06), lower mean arterial pressure (HR = 0.98, 95% CI: 0.97–1.00), and higher blood urea (HR = 1.01, 95% CI: 1.00–1.02) as independent predictors of long-term mortality. Conclusion: We found that older age and lower mean arterial pressure were significantly associated with the increased risk of in-hospital and long-term mortality in STEMI patients undergoing primary PCI. Our results indicate a necessity for more precise care and monitoring during hospitalization for such high-risk patients. © 2024 The Authors. Health Science Reports published by Wiley Periodicals LLC.
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