Tehran University of Medical Sciences

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Successful Allogeneic Hematopoietic Stem Cell Transplantation in a Child With Transfusion-Dependent Pyridoxine Refractory Hereditary Sideroblastic Anaemia



Rostami T1 ; Kiumarsi A1 ; Asl AAH1 ; Hoseini AS1 ; Mousavi A1
Authors
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Authors Affiliations
  1. 1. Hematology, Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Shariati Hospital, Tehran, Iran

Source: Hematology (Bulgaria) Published:2020

Abstract

We report a case of pyridoxine refractory, hereditary sideroblastic anaemia (HSA) in a 23 months old girl who underwent bone marrow stem cell transplantation (BMSCT) from his 28-year-old HLA-identical maternal uncle. By using short tandem repeat polymorphism, 95% donor cells were observed in peripheral blood on day +15, +30, +90 and until the present time; the patient did not develop any significant graft-versus-host disease or other transplant complications. One years after transplantation, the patient has a Lansky score1 of 100, with a normal cell blood count (CBC). © 2020 Bulgarian Medical Society of Hematology. All rights reserved.