Outcome of Guided Pulpal Regeneration in Immature Molar Teeth With Chronic Apical Abscess: A Case Report and Mini-Review Publisher

Summary: Can guided pulpal regeneration (GPR) yield different results? A study found varying root development after treating teeth with GPR despite similar protocols. Outcomes may not be predictable! #Dentistry #RootCanal

Kiafar M M ; Afkhami F ; Ghabraei S ; Peters O A ; Xu C ; Abaee S A
Source: Frontiers in Dentistry Published:2026

Abstract

This case report describes guided pulpal regeneration (GPR) of two immature permanent molar teeth with chronic apical abscess, thin dentinal walls, and open apices. Both teeth were treated with an identical protocol in two sessions, with minimum instrumentation with hand files, irrigation with 1.5% sodium hypochlorite (NaOCl), and application of 1:1 mixture of ciprofloxacin and metronidazole as an intracanal medicament, blood clot as a scaffold, and mineral trioxide aggregate (MTA) as the capping material. At the one-year follow-up, both treated teeth were asymptomatic. However, the root development procedure was different even in different roots of the same tooth, varying from only an increased thickness of dentinal walls to complete closure of the apex along with an increase in root length and dentinal wall thickness. It is concluded that the outcome of GPR is not completely predictable, and may vary among teeth with similar initial conditions and treatment approaches. Copyright © 2026 The Authors.