Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Bulge Region As a Putative Hair Follicle Stem Cells Niche: A Brief Review



Joulai Veijouye S1, 2 ; Yari A3 ; Heidari F4 ; Sajedi N5 ; Ghoroghi Moghani F6 ; Nobakht M1, 5, 7
Authors
Show Affiliations
Authors Affiliations
  1. 1. Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Dept. of Biology, University of Guilan, University Campus 2, Rasht, Iran
  3. 3. Dept. of Anatomy, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
  4. 4. Dept. of Anatomy, School of Medicine, Qom University of Medical Sciences, Qom, Iran
  5. 5. Dept. of Anatomy, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  6. 6. Dept. of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Anti-Microbial Resistance Research Center, Iran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Public Health Published:2017

Abstract

Background: Hair follicle stem cells exist in different sites. Most of the hair follicle stem cells are reside in niche called bulge. Bulge region is located between the opening of sebaceous gland and the attachment site of the arrector pili muscle. Methods: Data were collected using databases and resources of PubMed, Web of Science, Science Direct, Scopus, MEDLINE and their references from the earliest available published to identify English observational studies on hair follicle bulge region. Results: Bulge stem cells are pluripotent with high proliferative capacity. Specific markers allow the bulge cells to be isolated from mouse or human hair follicle. Stem cells isolated from bulge region are label retaining and slow cycling hence these cells are defined as label-retaining cells. Bulge cell populations, due to their plasticity nature are able to differentiate into distinct linage and could contribute in tissue regeneration. Conclusion: The current review discuss about bulge stem cells characteristics and biology including their cycle, location, plasticity, specific markers and regenerative nature. Also the differences between mouse and human hair follicles are investigated. © 2017, Iranian Journal of Public Health. All rights reserved.
Related Docs
1. In Vitro Induction Effect of 1,25(Oh)2D3 on Differentiation of Hair Follicle Stem Cell Into Keratinocyte, Biomedical Journal (2017)
2. Hair Follicle Generation by Injections of Adult Human Follicular Epithelial and Dermal Papilla Cells Into Nude Mice, Cell Journal (2017)
3. Human Platelet Lysate Versus Minoxidil Stimulates Hair Growth by Activating Anagen Promoting Signaling Pathways, Biomedicine and Pharmacotherapy (2016)
4. Hair Follicle As a Source of Pigment-Producing Cells for Treatment of Vitiligo: An Alternative to Epidermis?, Tissue Engineering and Regenerative Medicine (2020)
5. Defining Microrna Signatures of Hair Follicular Stem and Progenitor Cells in Healthy and Androgenic Alopecia Patients, Journal of Dermatological Science (2021)
6. Skin Stem Cells in Skin Cell Therapy, Journal of Skin and Stem Cell (2015)
Experts (# of related papers)
Mohammad Ali Nilforoushzadeh (3)