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Investigating Facilitatory Effects of Lithium on Methamphetamine-Induced Spatial Memory Impairments in Rat Publisher



Ghazvini H1 ; Tirgar F2 ; Khodamoradi M3 ; Tamijani SMS1 ; Niknamfar S4 ; Akbari E5 ; Nekahi M4 ; Tarjani N1 ; Ghalehnoei H1 ; Ardeshiri MR6
Authors
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Authors Affiliations
  1. 1. Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran
  2. 2. Department of Neuroscience and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Substance Abuse Prevention Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
  4. 4. Department of Neuroscience, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  5. 5. Department of Physiology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  6. 6. Immunogenetics Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Source: Basic and Clinical Neuroscience Published:2023


Abstract

Introduction: It has long been known that Methamphetamine (MA), as a psychostimulant, leads to long-lasting cognitive deficits. Previous studies have shown that lithium, a mood stabilizer, could facilitate cognitive ability in most of brain diseases. In current study the effects of lithium on spatial memory, hippocampal apoptosis and brain edema in METH-exposed rats are investigated. Methods: The present study 32 Wistar rats were used to examine the effects of lithium on spatial memory by the Morris water maze, hippocampal apoptosis using the TUNEL assay, and brain edema following MA administrations. Results: The findings indicated that treatment with lithium significantly ameliorated spatial learning and memory impairment in MA-treated rats. In addition, the findings showed that treatment with lithium significantly reduced brain edema and apoptosis in the CA1 neurons in MA -exposed rats. Conclusion: The results show that treatment with lithium can partially ameliorate the MA–induced neurocognitive deficits in rats, which may be related to its protective effect in the hippocampus. © 2023 Iran University of Medical Sciences. All rights reserved.
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