The Interaction Between Dietary Total Antioxidant Capacity and Mc4r Gene and Homa-Ir in Metabolically Healthy and Unhealthy Overweight and Obese Women

The Interaction Between Dietary Total Antioxidant Capacity and Mc4r Gene and Homa-Ir in Metabolically Healthy and Unhealthy Overweight and Obese Women Publisher

Elhamkia M¹ ; Setayesh L² ; Yarizadeh H³ ; Pooyan S³ ; Veisy Z³ ; Aghamohammadi V³ ; Casazza K⁴ ; Mirzaei K⁵

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1. Nutrition and Diet Therapy, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran
2. Nutrition and Diet Therapy, Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran
3. School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran
4. Marieb College of Health Human Services, Florida Gulf Coast University, Fort Myers, FL, United States
5. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

Source: Nutrition and Metabolic Insights Published:2022

Abstract

Introduction: The current prevalence of the metabolically healthy obesity is about 3%. Genetic and nutrition are influencers of such phenotypes. The main goal of this study was to assess the interaction between Dietary Total Antioxidant Capacity (DTAC) and the genotypes of MC4R and Insulin resistance in metabolically healthy/unhealthy overweight and obese women in Iran. Material And Methods: This cross-sectional study was conducted on 237 overweight-obese women with a mean age of 36. The value of Dietary total antioxidant capacity (DTAC) was calculated using the following indices: Total reactive antioxidant potential (TRAP), Trolox equivalent antioxidant capacity (TEAC), and ferric reducing ability of plasma (FRAP). The Metabolic health status was evaluated using the Karelis criteria. Melanocortin 4 receptor single nucleotide polymorphisms were determined by the restriction fragment length polymorphism (PCR-RFLP) method. Also, insulin resistance was evaluated through homeostasis model assessment (HOMA). Result: Our data noted that 72.96% of participants presented Unhealthy Metabolically and 26.94% Healthy Metabolically including 33.5% of the total had T/T genotype, 23.8% had the C/T genotype, and 42.5% had the C/C genotype (P =.05). A linear regression model test showed that the probability of metabolically healthy obesity was significantly higher in patients with the T/C genotype. The test value was statistically significant (95% CI: 0.000-0.001; P =.056, β = 0). No statistically significant relation was observed between study parameters and DTAC values. HOMA-Index was higher in all unhealthy subjects significantly. Conclusions: The findings indicated that there are significant associations between genotypes of rs1333048 SNP and DTAC. The C/C genotype subjects with higher DTAC had a better lipid profile and were metabolically healthier. © The Author(s) 2022.

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Style	Citing Format
MLA	Elhamkia M, et al.. "The Interaction Between Dietary Total Antioxidant Capacity and Mc4r Gene and Homa-Ir in Metabolically Healthy and Unhealthy Overweight and Obese Women." Nutrition and Metabolic Insights, vol. 15, no. , 2022, pp. -.
APA	Elhamkia M, Setayesh L, Yarizadeh H, Pooyan S, Veisy Z, Aghamohammadi V, Casazza K, Mirzaei K (2022). The Interaction Between Dietary Total Antioxidant Capacity and Mc4r Gene and Homa-Ir in Metabolically Healthy and Unhealthy Overweight and Obese Women. Nutrition and Metabolic Insights, 15(), -.
Chicago	Elhamkia M, Setayesh L, Yarizadeh H, Pooyan S, Veisy Z, Aghamohammadi V, Casazza K, Mirzaei K. "The Interaction Between Dietary Total Antioxidant Capacity and Mc4r Gene and Homa-Ir in Metabolically Healthy and Unhealthy Overweight and Obese Women." Nutrition and Metabolic Insights 15, no. (2022): -.
Harvard	Elhamkia M et al. (2022) 'The Interaction Between Dietary Total Antioxidant Capacity and Mc4r Gene and Homa-Ir in Metabolically Healthy and Unhealthy Overweight and Obese Women', Nutrition and Metabolic Insights, 15(), pp. -.
Vancouver	Elhamkia M, Setayesh L, Yarizadeh H, Pooyan S, Veisy Z, Aghamohammadi V, et al.. The Interaction Between Dietary Total Antioxidant Capacity and Mc4r Gene and Homa-Ir in Metabolically Healthy and Unhealthy Overweight and Obese Women. Nutrition and Metabolic Insights. 2022;15():-.
BibTex	@article{ author = {Elhamkia M and Setayesh L and Yarizadeh H and Pooyan S and Veisy Z and Aghamohammadi V and Casazza K and Mirzaei K}, title = {The Interaction Between Dietary Total Antioxidant Capacity and Mc4r Gene and Homa-Ir in Metabolically Healthy and Unhealthy Overweight and Obese Women}, journal = {Nutrition and Metabolic Insights}, volume = {15}, number = {}, pages = {-}, year = {2022} }
RIS	TY - JOUR AU - Elhamkia M AU - Setayesh L AU - Yarizadeh H AU - Pooyan S AU - Veisy Z AU - Aghamohammadi V AU - Casazza K AU - Mirzaei K TI - The Interaction Between Dietary Total Antioxidant Capacity and Mc4r Gene and Homa-Ir in Metabolically Healthy and Unhealthy Overweight and Obese Women JO - Nutrition and Metabolic Insights VL - 15 IS - SP - EP - PY - 2022 ER -

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